Gene description for Rrm1
Gene name ribonucleotide reductase M1
Gene symbol Rrm1
Other names/aliases RnrM1
Species Mus musculus
 Database cross references - Rrm1
ExoCarta ExoCarta_20133
Vesiclepedia VP_20133
Entrez Gene 20133
UniProt P07742  
 Rrm1 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Rrm1
Molecular Function
    oxidoreductase activity GO:0016491 IEA
    ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0004748 IDA
    catalytic activity GO:0003824 IEA
    nucleotide binding GO:0000166 IEA
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    purine nucleotide binding GO:0017076 IDA
Biological Process
    deoxyribonucleotide biosynthetic process GO:0009263 IDA
    protein heterotetramerization GO:0051290 IPI
    oxidation-reduction process GO:0055114 IDA
    metabolic process GO:0008152 IEA
    protein oligomerization GO:0051259 IPI
    DNA replication GO:0006260 IEA
Subcellular Localization
    nuclear envelope GO:0005635 ISO
    neuronal cell body GO:0043025 ISO
    extracellular exosome GO:0070062 ISO
    cell projection GO:0042995 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Rrm1 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Rrm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rrm1 is involved
PathwayEvidenceSource
Synthesis and interconversion of nucleotide di- and triphosphates IEA Reactome





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