Gene description for Taok1
Gene name TAO kinase 1
Gene symbol Taok1
Other names/aliases 2810468K05Rik
AU020252
D130018F14Rik
Map3k16
Markk
Psk2
mKIAA1361
Species Mus musculus
 Database cross references - Taok1
ExoCarta ExoCarta_216965
Entrez Gene 216965
UniProt Q5F2E8  
 Taok1 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Taok1
Molecular Function
    ATP binding GO:0005524 IEA
    MAP kinase kinase kinase activity GO:0004709 IBA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    protein kinase activator activity GO:0030295 ISO
    protein serine/threonine kinase activity GO:0004674 ISO
    kinase activity GO:0016301 IEA
    transferase activity GO:0016740 IEA
    protein kinase binding GO:0019901 ISO
    protein kinase activity GO:0004672 IEA
    nucleotide binding GO:0000166 IEA
Biological Process
    phosphorylation GO:0016310 IEA
    signal transduction by protein phosphorylation GO:0023014 IBA
    apoptotic process GO:0006915 IEA
    DNA repair GO:0006281 IEA
    positive regulation of stress-activated MAPK cascade GO:0032874 ISO
    positive regulation of JNK cascade GO:0046330 ISO
    regulation of cytoskeleton organization GO:0051493 ISO
    MAPK cascade GO:0000165 IBA
    activation of MAPKK activity GO:0000186 IBA
    regulation of apoptotic process GO:0042981 IBA
    regulation of mitotic cell cycle GO:0007346 IBA
    stress-activated protein kinase signaling cascade GO:0031098 IBA
    protein phosphorylation GO:0006468 ISO
    cellular response to DNA damage stimulus GO:0006974 ISO
    execution phase of apoptosis GO:0097194 ISO
    G2 DNA damage checkpoint GO:0031572 ISO
Subcellular Localization
    cytoplasm GO:0005737 IBA
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 IBA
 Experiment description of studies that identified Taok1 in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Taok1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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