Gene description for Umps
Gene name uridine monophosphate synthetase
Gene symbol Umps
Other names/aliases 1700095D23Rik
AA408257
AL033308
BB164745
Species Mus musculus
 Database cross references - Umps
ExoCarta ExoCarta_22247
Vesiclepedia VP_22247
Entrez Gene 22247
UniProt P13439  
 Umps identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Umps
Molecular Function
    lyase activity GO:0016829 IEA
    orotate phosphoribosyltransferase activity GO:0004588 ISO
    transferase activity GO:0016740 IEA
    carboxy-lyase activity GO:0016831 IEA
    orotidine-5'-phosphate decarboxylase activity GO:0004590 ISO
    catalytic activity GO:0003824 IEA
    transferase activity, transferring glycosyl groups GO:0016757 IEA
Biological Process
    pyrimidine nucleotide biosynthetic process GO:0006221 IEA
    UMP biosynthetic process GO:0006222 ISO
    'de novo' pyrimidine nucleobase biosynthetic process GO:0006207 IEA
    nucleoside metabolic process GO:0009116 IEA
    'de novo' UMP biosynthetic process GO:0044205 IEA
    metabolic process GO:0008152 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Umps in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Umps
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Umps is involved
PathwayEvidenceSource
Pyrimidine biosynthesis IEA Reactome





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