Gene description for Mfsd7b
Gene name major facilitator superfamily domain containing 7B
Gene symbol Mfsd7b
Other names/aliases 9630055N22Rik
FLVCR
Flvcr1
Species Mus musculus
 Database cross references - Mfsd7b
ExoCarta ExoCarta_226844
Entrez Gene 226844
UniProt B2RXV4  
 Mfsd7b identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Mfsd7b
Molecular Function
    heme transporter activity GO:0015232 ISO
Biological Process
    erythrocyte maturation GO:0043249 IEA
    spleen development GO:0048536 IMP
    blood vessel development GO:0001568 IMP
    multicellular organism growth GO:0035264 IMP
    erythrocyte differentiation GO:0030218 ISO
    mitochondrial transport GO:0006839 ISO
    in utero embryonic development GO:0001701 IMP
    embryonic digit morphogenesis GO:0042733 IMP
    transport GO:0006810 IEA
    embryonic skeletal system morphogenesis GO:0048704 IMP
    limb morphogenesis GO:0035108 IMP
    heme export GO:0097037 ISO
    heme transport GO:0015886 ISO
    regulation of organ growth GO:0046620 IMP
    transmembrane transport GO:0055085 IEA
    head morphogenesis GO:0060323 IMP
Subcellular Localization
    membrane GO:0016020 IEA
    mitochondrion GO:0005739 ISO
    plasma membrane GO:0005886 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Mfsd7b in exosomes
1
Experiment ID 214
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Mfsd7b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mfsd7b is involved
PathwayEvidenceSource
Iron uptake and transport IEA Reactome





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