Gene description for Aldob
Gene name aldolase B, fructose-bisphosphate
Gene symbol Aldob
Other names/aliases Aldo-2
Aldo2
BC016435
Species Mus musculus
 Database cross references - Aldob
ExoCarta ExoCarta_230163
Vesiclepedia VP_230163
Entrez Gene 230163
UniProt Q91Y97  
 Aldob identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aldob
Molecular Function
    fructose-1-phosphate aldolase activity GO:0061609 ISO
    identical protein binding GO:0042802 ISO
    fructose-bisphosphate aldolase activity GO:0004332 ISO
    lyase activity GO:0016829 IEA
    phosphatidylcholine binding GO:0031210 ISO
    cytoskeletal protein binding GO:0008092 ISO
    fructose binding GO:0070061 ISO
    ATPase binding GO:0051117 ISO
    catalytic activity GO:0003824 IEA
Biological Process
    response to peptide hormone GO:0043434 ISO
    vacuolar proton-transporting V-type ATPase complex assembly GO:0070072 ISO
    fructose metabolic process GO:0006000 ISO
    positive regulation of ATPase activity GO:0032781 ISO
    response to zinc ion GO:0010043 ISO
    NADH oxidation GO:0006116 ISO
    glycolytic process GO:0006096 ISO
    fructose 1,6-bisphosphate metabolic process GO:0030388 ISO
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 ISO
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    lysosome GO:0005764 ISO
    rough endoplasmic reticulum membrane GO:0030867 ISO
    cytosol GO:0005829 ISO
    smooth endoplasmic reticulum membrane GO:0030868 ISO
    centriolar satellite GO:0034451 ISO
    microtubule organizing center GO:0005815 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
    extracellular exosome GO:0070062 ISO
    cytoskeleton GO:0005856 IEA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Aldob in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aldob
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aldob is involved
PathwayEvidenceSource
Fructose catabolism IEA Reactome
Gluconeogenesis IEA Reactome
Glycolysis IEA Reactome





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