Gene description for Ffar2
Gene name free fatty acid receptor 2
Gene symbol Ffar2
Other names/aliases GPCR43
Gpr43
Species Mus musculus
 Database cross references - Ffar2
ExoCarta ExoCarta_233079
Entrez Gene 233079
UniProt Q8VCK6  
 Ffar2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ffar2
Molecular Function
    signal transducer activity GO:0004871 IEA
    lipid binding GO:0008289 IEA
    G-protein coupled receptor activity GO:0004930 ISO
Biological Process
    signal transduction GO:0007165 IEA
    cell surface pattern recognition receptor signaling pathway GO:0002752 ISO
    inflammatory response GO:0006954 IEA
    leukocyte chemotaxis involved in inflammatory response GO:0002232 IMP
    positive regulation of cytokine production involved in immune response GO:0002720 IMP
    positive regulation of acute inflammatory response to non-antigenic stimulus GO:0002879 IMP
    regulation of acute inflammatory response GO:0002673 IMP
    cellular response to fatty acid GO:0071398 ISO
    regulation of peptide hormone secretion GO:0090276 IMP
    positive regulation of interleukin-8 secretion GO:2000484 ISO
    immune system process GO:0002376 IEA
    lipid storage GO:0019915 IMP
    G-protein coupled receptor signaling pathway GO:0007186 ISO
    fat cell differentiation GO:0045444 IMP
    glucose homeostasis GO:0042593 IMP
    positive regulation of chemokine production GO:0032722 IMP
    mucosal immune response GO:0002385 IMP
Subcellular Localization
    membrane GO:0016020 IEA
    plasma membrane GO:0005886 ISO
    integral component of membrane GO:0016021 IEA
    cell projection GO:0042995 ISO
 Experiment description of studies that identified Ffar2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ffar2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ffar2 is involved
PathwayEvidenceSource
Free fatty acid receptors IEA Reactome
G alpha (q) signalling events IEA Reactome
G alpha (q) signalling events IEA Reactome





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