Gene description for DDX58
Gene name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Gene symbol	DDX58
Other names/aliases	RIG-I RIGI RLR-1 SGMRT2
Species	Homo sapiens
Database cross references - DDX58
ExoCarta	ExoCarta_23586
Entrez Gene	23586
HGNC	19102
MIM	609631
UniProt	O95786
DDX58 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for DDX58

Molecular Function     ATP binding GO:0005524 IEA     single-stranded RNA binding GO:0003727 IMP     helicase activity GO:0004386 IEA     double-stranded RNA binding GO:0003725 TAS     protein binding GO:0005515 IPI     identical protein binding GO:0042802 IPI     zinc ion binding GO:0008270 IDA     double-stranded DNA binding GO:0003690 IEA Biological Process     cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 TAS     positive regulation of interleukin-8 production GO:0032757 IDA     response to exogenous dsRNA GO:0043330 IEA     regulation of cell migration GO:0030334 IDA     positive regulation of interleukin-6 production GO:0032755 IDA     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IC     positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 IDA     positive regulation of interferon-alpha production GO:0032727 IMP     detection of virus GO:0009597 IDA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     innate immune response GO:0045087 TAS     negative regulation of type I interferon production GO:0032480 TAS     positive regulation of transcription factor import into nucleus GO:0042993 IDA     viral process GO:0016032 IEA     metabolic process GO:0008152 IEA     response to virus GO:0009615 TAS     positive regulation of interferon-beta production GO:0032728 IMP     RIG-I signaling pathway GO:0039529 IMP     positive regulation of gene expression GO:0010628 IDA     regulation of type III interferon production GO:0034344 TAS     positive regulation of defense response to virus by host GO:0002230 IMP Subcellular Localization     ruffle membrane GO:0032587 IDA     cytoplasm GO:0005737 IDA     actin cytoskeleton GO:0015629 IDA     cytosol GO:0005829 TAS     bicellular tight junction GO:0005923 IDA