Gene description for Cyp4a2
Gene name cytochrome P450, family 4, subfamily a, polypeptide 2
Gene symbol Cyp4a2
Other names/aliases Cyp4a11
Species Rattus norvegicus
 Database cross references - Cyp4a2
ExoCarta ExoCarta_24306
Entrez Gene 24306
UniProt P20816  
 Cyp4a2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cyp4a2
Molecular Function
    iron ion binding GO:0005506 IEA
    fatty acid binding GO:0005504 IDA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 IEA
    arachidonic acid 11,12-epoxygenase activity GO:0008405 TAS
    heme binding GO:0020037 IEA
    arachidonic acid omega-hydroxylase activity GO:0052869 IEA
    alkane 1-monooxygenase activity GO:0018685 IMP
    arachidonic acid monooxygenase activity GO:0008391 IMP
    monooxygenase activity GO:0004497 IEA
    arachidonic acid binding GO:0050544 IDA
Biological Process
    oxidation-reduction process GO:0055114 IEA
    linoleic acid metabolic process GO:0043651 IDA
    arachidonic acid metabolic process GO:0019369 TAS
    response to hormone GO:0009725 IEP
    response to drug GO:0042493 IEP
    kidney development GO:0001822 IEP
    lauric acid metabolic process GO:0048252 IDA
    icosanoid biosynthetic process GO:0046456 IMP
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified Cyp4a2 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cyp4a2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cyp4a2 is involved
PathwayEvidenceSource
Fatty acids IEA Reactome
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) IEA Reactome





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