Gene description for Myh11
Gene name myosin, heavy chain 11, smooth muscle
Gene symbol Myh11
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Myh11
ExoCarta ExoCarta_24582
Entrez Gene 24582
 Myh11 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
Hepatocytes 19367702    
 Gene ontology annotations for Myh11
Molecular Function
    actin binding GO:0003779 IEA
    calmodulin binding GO:0005516 IEA
    structural constituent of muscle GO:0008307 NAS
    ATP binding GO:0005524 IEA
    motor activity GO:0003774 ISO
Biological Process
    metabolic process GO:0008152 IEA
    cardiac muscle fiber development GO:0048739 ISO
    elastic fiber assembly GO:0048251 ISO
    smooth muscle contraction GO:0006939 ISO
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 ISO
Subcellular Localization
    brush border GO:0005903 ISO
    myofibril GO:0030016 IEA
    muscle myosin complex GO:0005859 NAS
    smooth muscle contractile fiber GO:0030485 ISO
    melanosome GO:0042470 IEA
    stress fiber GO:0001725 ISO
    extracellular exosome GO:0070062 ISO
    myosin complex GO:0016459 ISO
    myosin filament GO:0032982 IEA
 Experiment description of studies that identified Myh11 in exosomes
1
Experiment ID 225
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Myh11
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Myh11 is involved
No pathways found





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