Gene description for Alpl
Gene name alkaline phosphatase, liver/bone/kidney
Gene symbol Alpl
Other names/aliases Akp2
PHOA
Species Rattus norvegicus
 Database cross references - Alpl
ExoCarta ExoCarta_25586
Entrez Gene 25586
UniProt P08289  
 Alpl identified in exosomes derived from the following tissue/cell type
Urine 20535238    
 Gene ontology annotations for Alpl
Molecular Function
    pyrophosphatase activity GO:0016462 ISO
    metal ion binding GO:0046872 IEA
    alkaline phosphatase activity GO:0004035 TAS
Biological Process
    cellular response to organic cyclic compound GO:0071407 ISO
    response to lipopolysaccharide GO:0032496 IEP
    response to glucocorticoid GO:0051384 IDA
    developmental process involved in reproduction GO:0003006 ISO
    dephosphorylation GO:0016311 ISO
    osteoblast differentiation GO:0001649 ISO
    cementum mineralization GO:0071529 IEP
    response to vitamin D GO:0033280 ISO
    endochondral ossification GO:0001958 ISO
    response to antibiotic GO:0046677 ISO
Subcellular Localization
    proteinaceous extracellular matrix GO:0005578 ISO
    membrane GO:0016020 ISO
    extracellular exosome GO:0070062 ISO
    anchored component of membrane GO:0031225 IEA
    extracellular space GO:0005615 IDA
    extracellular membrane-bounded organelle GO:0065010 ISO
    plasma membrane GO:0005886 ISO
    extracellular matrix GO:0031012 IEA
 Experiment description of studies that identified Alpl in exosomes
1
Experiment ID 192
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
CD63|CD81|FLOT
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20535238    
Organism Rattus norvegicus
Experiment description Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.
Authors Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez M.
Journal name Proteomics Clin Appl
Publication year 2010
Sample Urine
Sample name Urine - Rats of liver injury
Isolation/purification methods Differential centrifugation
Filtration
UltracentrifugationSucrose cushion
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Alpl
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Alpl is involved
No pathways found





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