Gene description for Adgrg1
Gene name adhesion G protein-coupled receptor G1
Gene symbol Adgrg1
Other names/aliases Gpr56
Species Rattus norvegicus
 Database cross references - Adgrg1
ExoCarta ExoCarta_260326
Entrez Gene 260326
 Adgrg1 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Adgrg1
Molecular Function
    extracellular matrix binding GO:0050840 ISS
    G-protein coupled receptor activity GO:0004930 ISS
    collagen binding GO:0005518 ISS
Biological Process
    negative regulation of cell proliferation GO:0008285 ISS
    positive regulation of Rho protein signal transduction GO:0035025 ISS
    cerebral cortex radial glia guided migration GO:0021801 ISS
    positive regulation of cell adhesion GO:0045785 ISS
    negative regulation of neuron migration GO:2001223 ISS
    G-protein coupled receptor signaling pathway GO:0007186 ISO
    cerebral cortex regionalization GO:0021796 ISO
    protein kinase C signaling GO:0070528 ISS
    brain development GO:0007420 ISO
    layer formation in cerebral cortex GO:0021819 ISS
    Rho protein signal transduction GO:0007266 ISS
    vascular endothelial growth factor production GO:0010573 ISS
    angiogenesis GO:0001525 ISS
    positive regulation of neural precursor cell proliferation GO:2000179 ISO
    cell adhesion GO:0007155 IEA
Subcellular Localization
    extracellular region GO:0005576 IEA
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 ISO
    glial limiting end-foot GO:0097451 ISS
    intracellular GO:0005622 ISS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Adgrg1 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Adgrg1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Adgrg1 is involved
No pathways found





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