Gene description for Cyp2d1
Gene name cytochrome P450, family 2, subfamily d, polypeptide 1
Gene symbol Cyp2d1
Other names/aliases Cyp2d9
Species Rattus norvegicus
 Database cross references - Cyp2d1
ExoCarta ExoCarta_266684
Entrez Gene 266684
UniProt P10633  
 Cyp2d1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cyp2d1
Molecular Function
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IBA
    steroid hydroxylase activity GO:0008395 IBA
    oxygen binding GO:0019825 IBA
    aromatase activity GO:0070330 IEA
    arachidonic acid epoxygenase activity GO:0008392 IBA
    monooxygenase activity GO:0004497 IDA
    iron ion binding GO:0005506 IEA
    heme binding GO:0020037 IBA
Biological Process
    oxidation-reduction process GO:0055114 IBA
    exogenous drug catabolic process GO:0042738 IBA
    response to organic cyclic compound GO:0014070 IEP
    response to organic substance GO:0010033 IEP
    response to drug GO:0042493 IDA
    arachidonic acid metabolic process GO:0019369 IBA
    xenobiotic metabolic process GO:0006805 IBA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    cytoplasm GO:0005737 IDA
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified Cyp2d1 in exosomes
1
Experiment ID 35
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD81|CD63
EV Membrane markers
HSPA5
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cyp2d1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cyp2d1 is involved
PathwayEvidenceSource
Xenobiotics IEA Reactome





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