Gene description for Ak3
Gene name adenylate kinase 3
Gene symbol Ak3
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ak3
ExoCarta ExoCarta_26956
Entrez Gene 26956
UniProt P29411  
 Ak3 identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Ak3
Molecular Function
    GTP binding GO:0005525 IEA
    identical protein binding GO:0042802 IDA
    nucleoside triphosphate adenylate kinase activity GO:0046899 ISO
    adenylate kinase activity GO:0004017 ISO
    ATP binding GO:0005524 IEA
Biological Process
    AMP phosphorylation GO:0006756 IDA
    GTP metabolic process GO:0046039 ISO
    cerebellum development GO:0021549 IEP
    ATP metabolic process GO:0046034 IDA
    dATP metabolic process GO:0046060 IDA
    UTP metabolic process GO:0046051 ISO
    protein homooligomerization GO:0051260 IDA
    response to starvation GO:0042594 IEP
    ADP biosynthetic process GO:0006172 IEA
    nucleotide phosphorylation GO:0046939 IEA
    olfactory bulb development GO:0021772 IEP
    liver development GO:0001889 IEP
    ITP metabolic process GO:0046041 ISO
    muscle organ development GO:0007517 IEP
    AMP metabolic process GO:0046033 ISO
Subcellular Localization
    mitochondrial intermembrane space GO:0005758 IDA
    mitochondrion GO:0005739 ISS
    mitochondrial matrix GO:0005759 ISO
 Experiment description of studies that identified Ak3 in exosomes
1
Experiment ID 225
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Ak3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ak3 is involved
No pathways found





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