Gene description for B3gnt6
Gene name UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)
Gene symbol B3gnt6
Other names/aliases BC039789
Core-3
Core3
Species Mus musculus
 Database cross references - B3gnt6
ExoCarta ExoCarta_272411
Entrez Gene 272411
UniProt Q3USF0  
 B3gnt6 identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for B3gnt6
Molecular Function
    phenanthrol glycosyltransferase activity GO:0019112 IEA
    mannosyltransferase activity GO:0000030 IEA
    salicylic acid glucosyltransferase (glucoside-forming) activity GO:0052640 IEA
    dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity GO:0052824 IEA
    transferase activity GO:0016740 IEA
    galactosyltransferase activity GO:0008378 ISO
    salicylic acid glucosyltransferase (ester-forming) activity GO:0052639 IEA
    dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0042283 IEA
    acetylgalactosaminyltransferase activity GO:0008376 IEA
    9-phenanthrol glycosyltransferase activity GO:0018717 IEA
    cellulose synthase activity GO:0016759 IEA
    glycolipid mannosyltransferase activity GO:0004376 IEA
    9-phenanthrol UDP-glucuronosyltransferase activity GO:0018715 IEA
    lipopolysaccharide-1,5-galactosyltransferase activity GO:0035496 IEA
    alpha-1,3-galactosyltransferase activity GO:0001962 IEA
    alpha-(1->3)-fucosyltransferase activity GO:0046920 IEA
    cytokinin 9-beta-glucosyltransferase activity GO:0080062 IEA
    alpha-(1->6)-fucosyltransferase activity GO:0046921 IEA
    inositol phosphoceramide synthase activity GO:0045140 IEA
    dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0033556 IEA
    oligosaccharyl transferase activity GO:0004576 IEA
    glucosyltransferase activity GO:0046527 IEA
    benzoic acid glucosyltransferase activity GO:0052641 IEA
    acetylglucosaminyltransferase activity GO:0008375 IEA
    lipopolysaccharide-1,6-galactosyltransferase activity GO:0008921 IEA
    alpha-1,6-mannosyltransferase activity GO:0000009 IEA
    fucosyltransferase activity GO:0008417 IEA
    alpha-1,3-mannosyltransferase activity GO:0000033 IEA
    transferase activity, transferring glycosyl groups GO:0016757 IEA
    dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity GO:0004583 IEA
    chondroitin hydrolase activity GO:0052757 IEA
    1-phenanthrol glycosyltransferase activity GO:0018716 IEA
    indole-3-butyrate beta-glucosyltransferase activity GO:0052638 IEA
    beta-1,4-mannosyltransferase activity GO:0019187 IEA
    alpha-1,2-galactosyltransferase activity GO:0031278 IEA
    UDP-glucose:glycoprotein glucosyltransferase activity GO:0003980 IEA
    dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0042281 IEA
    O antigen polymerase activity GO:0008755 IEA
    1,2-dihydroxy-phenanthrene glycosyltransferase activity GO:0018718 IEA
    alpha-1,2-mannosyltransferase activity GO:0000026 IEA
Biological Process
    protein glycosylation GO:0006486 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    Golgi apparatus GO:0005794 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified B3gnt6 in exosomes
1
Experiment ID 264
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for B3gnt6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which B3gnt6 is involved
PathwayEvidenceSource
O-linked glycosylation of mucins IEA Reactome





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