Gene description for C3
Gene name complement component 3
Gene symbol C3
Other names/aliases -
Species Bos taurus
 Database cross references - C3
ExoCarta ExoCarta_280677
Entrez Gene 280677
UniProt Q2UVX4  
 C3 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for C3
Molecular Function
    C5L2 anaphylatoxin chemotactic receptor binding GO:0031715 ISS
    endopeptidase inhibitor activity GO:0004866 IEA
Biological Process
    fatty acid metabolic process GO:0006631 IEA
    positive regulation of lipid storage GO:0010884 ISS
    inflammatory response GO:0006954 IEA
    positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 ISS
    regulation of triglyceride biosynthetic process GO:0010866 ISS
    positive regulation of protein phosphorylation GO:0001934 ISS
    complement activation, classical pathway GO:0006958 IEA
    negative regulation of endopeptidase activity GO:0010951 IEA
    complement activation, alternative pathway GO:0006957 IEA
    positive regulation of glucose transport GO:0010828 ISS
Subcellular Localization
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified C3 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for C3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which C3 is involved
No pathways found





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