Gene description for ARRB1
Gene name arrestin, beta 1
Gene symbol ARRB1
Other names/aliases -
Species Bos taurus
 Database cross references - ARRB1
ExoCarta ExoCarta_281637
Entrez Gene 281637
UniProt P17870  
 ARRB1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for ARRB1
Molecular Function
    angiotensin receptor binding GO:0031701 IEA
    GTPase activator activity GO:0005096 IEA
    transcription factor binding GO:0008134 IEA
    mitogen-activated protein kinase kinase binding GO:0031434 IEA
    insulin-like growth factor receptor binding GO:0005159 IEA
    ubiquitin protein ligase binding GO:0031625 IEA
    transcription regulatory region DNA binding GO:0044212 IEA
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IEA
Biological Process
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IEA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 IEA
    positive regulation of protein binding GO:0032092 IEA
    stress fiber assembly GO:0043149 IEA
    G-protein coupled receptor internalization GO:0002031 IEA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA
    negative regulation of interleukin-6 production GO:0032715 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IEA
    phototransduction GO:0007602 IEA
    protein ubiquitination GO:0016567 IEA
    transcription from RNA polymerase II promoter GO:0006366 IEA
    negative regulation of protein ubiquitination GO:0031397 IEA
    negative regulation of interleukin-8 production GO:0032717 IEA
    positive regulation of receptor internalization GO:0002092 ISS
    protein transport GO:0015031 IEA
    positive regulation of GTPase activity GO:0043547 IEA
    positive regulation of histone H4 acetylation GO:0090240 IEA
    positive regulation of Rho protein signal transduction GO:0035025 IEA
    positive regulation of protein phosphorylation GO:0001934 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IEA
    coated pit GO:0005905 IEA
    nucleoplasm GO:0005654 IEA
    pseudopodium GO:0031143 IEA
    cytoplasmic vesicle GO:0031410 IDA
    chromatin GO:0000785 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified ARRB1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARRB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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