Gene description for Cyp2d5
Gene name cytochrome P450, family 2, subfamily d, polypeptide 5
Gene symbol Cyp2d5
Other names/aliases Cyp2d10
Species Rattus norvegicus
 Database cross references - Cyp2d5
ExoCarta ExoCarta_286963
Entrez Gene 286963
UniProt P12939  
 Cyp2d5 identified in exosomes derived from the following tissue/cell type
Hepatocytes 19367702    
 Gene ontology annotations for Cyp2d5
Molecular Function
    aromatase activity GO:0070330 IEA
    heme binding GO:0020037 IEA
    oxygen binding GO:0019825 IBA
    steroid hydroxylase activity GO:0008395 IBA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 IEA
    monooxygenase activity GO:0004497 TAS
    iron ion binding GO:0005506 IEA
    arachidonic acid epoxygenase activity GO:0008392 IBA
Biological Process
    exogenous drug catabolic process GO:0042738 IBA
    arachidonic acid metabolic process GO:0019369 IBA
    xenobiotic metabolic process GO:0006805 IBA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    cytoplasm GO:0005737 IBA
    intracellular membrane-bounded organelle GO:0043231 IBA
 Experiment description of studies that identified Cyp2d5 in exosomes
1
Experiment ID 35
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD81|CD63
EV Membrane markers
✔
HSPA5
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19367702    
Organism Rattus norvegicus
Experiment description Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes.
Authors Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM
Journal name JPR
Publication year 2008
Sample Hepatocytes
Sample name Hepatocytes
Isolation/purification methods Differential centrifugation
Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
 Protein-protein interactions for Cyp2d5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cyp2d5 is involved
No pathways found





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