Gene description for Ctns
Gene name cystinosin, lysosomal cystine transporter
Gene symbol Ctns
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ctns
ExoCarta ExoCarta_287478
Entrez Gene 287478
 Ctns identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Ctns
Molecular Function
    L-cystine transmembrane transporter activity GO:0015184 ISO
    molecular_function GO:0003674 ND
Biological Process
    L-alpha-amino acid transmembrane transport GO:1902475 ISO
    visual learning GO:0008542 ISO
    cognition GO:0050890 ISO
    long-term memory GO:0007616 ISO
    adult walking behavior GO:0007628 ISO
    grooming behavior GO:0007625 ISO
    biological_process GO:0008150 ND
    L-cystine transport GO:0015811 ISO
    glutathione metabolic process GO:0006749 ISO
    lens development in camera-type eye GO:0002088 ISO
    ATP metabolic process GO:0046034 ISO
    brain development GO:0007420 ISO
Subcellular Localization
    lysosomal membrane GO:0005765 ISO
    lysosome GO:0005764 ISO
    cellular_component GO:0005575 ND
    intracellular membrane-bounded organelle GO:0043231 ISO
    extracellular exosome GO:0070062 ISO
    intermediate filament cytoskeleton GO:0045111 ISO
    plasma membrane GO:0005886 ISO
    late endosome GO:0005770 ISO
    early endosome GO:0005769 ISO
 Experiment description of studies that identified Ctns in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Ctns
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ctns is involved
No pathways found





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