Gene description for Mcu
Gene name mitochondrial calcium uniporter
Gene symbol Mcu
Other names/aliases Ccdc109a
Species Rattus norvegicus
 Database cross references - Mcu
ExoCarta ExoCarta_294560
Entrez Gene 294560
 Mcu identified in exosomes derived from the following tissue/cell type
Adipocytes 25998041    
 Gene ontology annotations for Mcu
Molecular Function
    calcium channel activity GO:0005262 ISO
    identical protein binding GO:0042802 ISO
    uniporter activity GO:0015292 ISO
Biological Process
    glucose homeostasis GO:0042593 ISO
    protein complex oligomerization GO:0035786 ISO
    positive regulation of insulin secretion GO:0032024 ISO
    calcium ion transmembrane import into mitochondrion GO:0036444 ISO
    mitochondrial calcium ion transport GO:0006851 ISO
    calcium-mediated signaling GO:0019722 ISO
    mitochondrial calcium ion homeostasis GO:0051560 IMP
    positive regulation of mitochondrial calcium ion concentration GO:0051561 ISO
Subcellular Localization
    calcium channel complex GO:0034704 ISO
    mitochondrion GO:0005739 ISO
    cell GO:0005623 ISO
    integral component of mitochondrial inner membrane GO:0031305 ISO
    intracellular GO:0005622 ISO
    uniplex complex GO:1990246 ISO
    mitochondrial inner membrane GO:0005743 ISO
 Experiment description of studies that identified Mcu in exosomes
Experiment ID 225
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25998041    
Organism Rattus norvegicus
Experiment description Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats.
Authors Lee JE, Moon PG, Lee IK, Baek MC
Journal name Protein J
Publication year 2015
Sample Adipocytes
Sample name Adipocytes
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for Mcu
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Mcu is involved
No pathways found

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