Gene description for Ccl20
Gene name chemokine (C-C motif) ligand 20
Gene symbol Ccl20
Other names/aliases ST38
Scya20
Species Rattus norvegicus
 Database cross references - Ccl20
ExoCarta ExoCarta_29538
Entrez Gene 29538
UniProt P97884  
 Ccl20 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Ccl20
Molecular Function
    cytokine activity GO:0005125 ISO
    chemokine activity GO:0008009 IDA
Biological Process
    cellular response to organic substance GO:0071310 IEP
    chemotaxis GO:0006935 IDA
    immune response GO:0006955 IEA
    positive regulation of T cell migration GO:2000406 ISO
    positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 IDA
    inflammatory response GO:0006954 IEA
    cell chemotaxis GO:0060326 IEA
    cellular response to lipopolysaccharide GO:0071222 IEP
    wound healing GO:0042060 IEP
    positive regulation of interleukin-1 alpha biosynthetic process GO:0050726 IDA
    cellular response to lipoteichoic acid GO:0071223 IEP
Subcellular Localization
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified Ccl20 in exosomes
1
Experiment ID 92
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|GAPDH
EV Cytosolic markers
✔
CD9|CD151
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|GAPDH
EV Cytosolic markers
✔
CD9|CD151
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Ccl20
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ccl20 is involved
PathwayEvidenceSource
Chemokine receptors bind chemokines IEA Reactome
G alpha (i) signalling events IEA Reactome





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