Gene description for Uchl1
Gene name ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Gene symbol Uchl1
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Uchl1
ExoCarta ExoCarta_29545
Vesiclepedia VP_29545
Entrez Gene 29545
UniProt Q00981  
 Uchl1 identified in exosomes derived from the following tissue/cell type
Plasma 34654817    
Plasma 34654817    
 Gene ontology annotations for Uchl1
Molecular Function
    ligase activity GO:0016874 IEA
    alpha-2A adrenergic receptor binding GO:0031694 ISO
    omega peptidase activity GO:0008242 ISO
    ubiquitin-specific protease activity GO:0004843 ISO
    ubiquitin binding GO:0043130 ISO
    ubiquitin protein ligase binding GO:0031625 ISO
    cysteine-type endopeptidase activity GO:0004197 ISO
Biological Process
    adult walking behavior GO:0007628 ISO
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    neuromuscular process GO:0050905 ISO
    response to ischemia GO:0002931 ISO
    muscle fiber development GO:0048747 ISO
    proteolysis GO:0006508 ISO
    eating behavior GO:0042755 ISO
    sensory perception of pain GO:0019233 IDA
    cell proliferation GO:0008283 ISO
    axon transport of mitochondrion GO:0019896 ISO
    protein deubiquitination GO:0016579 ISO
    axonogenesis GO:0007409 ISO
    negative regulation of MAP kinase activity GO:0043407 ISO
    axon target recognition GO:0007412 ISO
Subcellular Localization
    neuron projection terminus GO:0044306 ISO
    plasma membrane GO:0005886 ISO
    axon GO:0030424 ISO
    cell GO:0005623 ISO
    intracellular GO:0005622 ISO
    extracellular exosome GO:0070062 ISO
    neuronal cell body GO:0043025 ISO
    cytoplasm GO:0005737 ISO
    endoplasmic reticulum membrane GO:0005789 IEA
    nucleoplasm GO:0005654 ISO
    myelin sheath GO:0043209 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Uchl1 in exosomes
1
Experiment ID 1154
MISEV standards
EM
EV Biophysical techniques
Tsg101|Cd9|Cd63|Uchl1
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 34654817    
Organism Rattus norvegicus
Experiment description Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors
Authors Xia W, Xie J, Cai Z, Liu X, Wen J, Cui ZK, Zhao R, Zhou X, Chen J, Mao X, Gu Z, Zou Z, Zou Z, Zhang Y, Zhao M, Mac M, Song Q, Bai X.
Journal name Nat Commun
Publication year 2021
Sample Plasma
Sample name Sham - Sprague-Dawley rat
Isolation/purification methods ExoQuick Kit
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
miRNA sequencing
qRT-PCR
Mass spectrometry
2
Experiment ID 1155
MISEV standards
EV Biophysical techniques
Tsg101|Cd9|Cd63|Uchl1
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 34654817    
Organism Rattus norvegicus
Experiment description Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors
Authors Xia W, Xie J, Cai Z, Liu X, Wen J, Cui ZK, Zhao R, Zhou X, Chen J, Mao X, Gu Z, Zou Z, Zou Z, Zhang Y, Zhao M, Mac M, Song Q, Bai X.
Journal name Nat Commun
Publication year 2021
Sample Plasma
Sample name Post-traumatic brain injury surgery (24 h) - Sprague-Dawley rat
Isolation/purification methods ExoQuick Kit
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
miRNA sequencing
qRT-PCR
Mass spectrometry
 Protein-protein interactions for Uchl1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Uchl1 is involved
No pathways found





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