Gene description for Slc1a4
Gene name solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Gene symbol Slc1a4
Other names/aliases ASCT1
Species Rattus norvegicus
 Database cross references - Slc1a4
ExoCarta ExoCarta_305540
Entrez Gene 305540
 Slc1a4 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Slc1a4
Molecular Function
    L-serine transmembrane transporter activity GO:0015194 ISO
    sodium:dicarboxylate symporter activity GO:0017153 IEA
    L-threonine transmembrane transporter activity GO:0015195 ISO
    L-cystine transmembrane transporter activity GO:0015184 ISO
    neutral amino acid transmembrane transporter activity GO:0015175 ISO
    chloride channel activity GO:0005254 ISO
    L-hydroxyproline transmembrane transporter activity GO:0034590 ISO
    L-proline transmembrane transporter activity GO:0015193 ISO
    L-alanine transmembrane transporter activity GO:0015180 ISO
Biological Process
    amino acid transmembrane transport GO:0003333 ISO
    cognition GO:0050890 ISO
    chloride transport GO:0006821 ISO
    L-alanine transport GO:0015808 ISO
    neutral amino acid transport GO:0015804 ISO
    chloride transmembrane transport GO:1902476 ISO
    threonine transport GO:0015826 ISO
    dicarboxylic acid transport GO:0006835 IEA
    proline transmembrane transport GO:0035524 ISO
    proline transport GO:0015824 ISO
    L-serine transport GO:0015825 ISO
    hydroxyproline transport GO:0034589 ISO
    L-cystine transport GO:0015811 ISO
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 ISO
Subcellular Localization
    microtubule organizing center GO:0005815 ISO
    neuronal cell body GO:0043025 IDA
    centrosome GO:0005813 ISO
    membrane GO:0016020 ISO
    dendrite GO:0030425 IDA
    extracellular exosome GO:0070062 ISO
    cell surface GO:0009986 ISO
    intermediate filament GO:0005882 ISO
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Slc1a4 in exosomes
1
Experiment ID 90
ISEV standards
EM
EV Biophysical techniques
HSC70|HSP90|TSG101
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Slc1a4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc1a4 is involved
No pathways found





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