Gene description for Anxa8
Gene name annexin A8
Gene symbol Anxa8
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Anxa8
ExoCarta ExoCarta_306283
Entrez Gene 306283
UniProt Q4FZU6  
 Anxa8 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Anxa8
Molecular Function
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 ISO
    calcium ion binding GO:0005509 ISO
    actin filament binding GO:0051015 ISO
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 ISO
    calcium-dependent phospholipid binding GO:0005544 ISO
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 ISO
    molecular_function GO:0003674 ND
Biological Process
    negative regulation of serine-type endopeptidase activity GO:1900004 ISO
    negative regulation of phospholipase A2 activity GO:1900138 ISO
    endosome organization GO:0007032 ISO
    blood coagulation GO:0007596 IEA
    endosomal transport GO:0016197 ISO
    biological_process GO:0008150 ND
Subcellular Localization
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 ISO
    late endosome membrane GO:0031902 ISO
    cellular_component GO:0005575 ND
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Anxa8 in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Anxa8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Anxa8 is involved
No pathways found





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