Gene description for Ube2m
Gene name ubiquitin-conjugating enzyme E2M
Gene symbol Ube2m
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Ube2m
ExoCarta ExoCarta_361509
Entrez Gene 361509
 Ube2m identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Ube2m
Molecular Function
    NEDD8 transferase activity GO:0019788 ISO
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin-protein transferase activity GO:0004842 ISO
    ribosomal S6-glutamic acid ligase activity GO:0018169 ISO
    molecular_function GO:0003674 ND
    ubiquitin protein ligase binding GO:0031625 IBA
Biological Process
    protein neddylation GO:0045116 ISO
    positive regulation of neuron apoptotic process GO:0043525 IMP
    cellular protein modification process GO:0006464 ISO
    protein ubiquitination GO:0016567 ISO
Subcellular Localization
    cellular_component GO:0005575 ND
    cytoplasm GO:0005737 IBA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Ube2m in exosomes
Experiment ID 98
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 2
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Ube2m
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ube2m is involved
No pathways found

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