Gene description for Carm1
Gene name coactivator-associated arginine methyltransferase 1
Gene symbol Carm1
Other names/aliases Prmt4
Species Rattus norvegicus
 Database cross references - Carm1
ExoCarta ExoCarta_363026
Entrez Gene 363026
UniProt Q4AE70  
 Carm1 identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Carm1
Molecular Function
    protein homodimerization activity GO:0042803 ISO
    protein binding GO:0005515 IPI
    protein methyltransferase activity GO:0008276 ISO
    histone-arginine N-methyltransferase activity GO:0008469 ISO
    histone methyltransferase activity (H3-R17 specific) GO:0035642 ISS
    transcription coactivator activity GO:0003713 ISS
    histone methyltransferase activity GO:0042054 ISS
    protein-arginine N-methyltransferase activity GO:0016274 ISS
    lysine-acetylated histone binding GO:0070577 ISS
    ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 ISS
    transcription regulatory region DNA binding GO:0044212 ISS
    protein-arginine omega-N asymmetric methyltransferase activity GO:0035242 ISS
Biological Process
    response to cAMP GO:0051591 IDA
    mRNA processing GO:0006397 IEA
    regulation of intracellular estrogen receptor signaling pathway GO:0033146 ISS
    pathogenesis GO:0009405 IEA
    histone methylation GO:0016571 ISO
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of dendrite development GO:2000171 IMP
    intracellular steroid hormone receptor signaling pathway GO:0030518 ISO
    regulation of transcription, DNA-templated GO:0006355 ISO
    RNA splicing GO:0008380 IEA
    histone arginine methylation GO:0034969 ISS
    regulation of growth plate cartilage chondrocyte proliferation GO:0003420 ISO
    positive regulation of fat cell differentiation GO:0045600 ISS
    peptidyl-arginine methylation, to asymmetrical-dimethyl arginine GO:0019919 ISO
    endochondral bone morphogenesis GO:0060350 ISO
    histone H3-R17 methylation GO:0034971 ISS
    histone H3-R2 methylation GO:0034970 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    protein methylation GO:0006479 ISO
    intracellular estrogen receptor signaling pathway GO:0030520 ISO
    negative regulation of protein binding GO:0032091 ISO
    aging GO:0007568 IEP
    regulation of mRNA binding GO:1902415 IMP
Subcellular Localization
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
    cytosol GO:0005829 ISS
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Carm1 in exosomes
1
Experiment ID 95
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D7 Rep 1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.25 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Carm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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