Gene description for Fdh
Gene name Formaldehyde dehydrogenase
Gene symbol Fdh
Other names/aliases ADHX
ADHX_DROME
CG6598
DmelCG6598
GSNOR
ODH
Odh
fdh
gfd
gfd/odh
odh
Species Drosophila melanogaster
 Database cross references - Fdh
ExoCarta ExoCarta_41311
Entrez Gene 41311
UniProt P46415  
 Fdh identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Fdh
Molecular Function
    zinc ion binding GO:0008270 IEA
    S-(hydroxymethyl)glutathione dehydrogenase activity GO:0051903 IDA
    octanol dehydrogenase activity GO:0004552 IDA
    S-nitrosoglutathione reductase activity GO:0080007 IMP
    alcohol dehydrogenase (NAD) activity GO:0004022 IDA
Biological Process
    ethanol oxidation GO:0006069 IEA
    alcohol metabolic process GO:0006066 IC
    regulation of nitric oxide metabolic process GO:0080164 IC
    regulation of peptidyl-cysteine S-nitrosylation GO:2000169 IMP
    visual learning GO:0008542 IMP
 Experiment description of studies that identified Fdh in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Fdh
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fdh is involved
PathwayEvidenceSource
Abacavir metabolism IEA Reactome
Ethanol oxidation IEA Reactome
RA biosynthesis pathway IEA Reactome





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