Gene description for HGS
Gene name hepatocyte growth factor-regulated tyrosine kinase substrate
Gene symbol HGS
Other names/aliases HRS
Species Bos taurus
 Database cross references - HGS
ExoCarta ExoCarta_511582
Entrez Gene 511582
UniProt Q0V8S0  
 HGS identified in exosomes derived from the following tissue/cell type
Milk 23459212    
 Gene ontology annotations for HGS
Molecular Function
    protein domain specific binding GO:0019904 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    membrane invagination GO:0010324 IEA
    positive regulation of gene expression GO:0010628 IEA
    negative regulation of JAK-STAT cascade GO:0046426 IEA
    protein targeting to lysosome GO:0006622 IEA
    protein localization to membrane GO:0072657 IEA
    positive regulation of exosomal secretion GO:1903543 IEA
Subcellular Localization
    multivesicular body membrane GO:0032585 IEA
    extracellular exosome GO:0070062 IEA
    early endosome membrane GO:0031901 IEA
 Experiment description of studies that identified HGS in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HGS
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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