Gene description for Pla2g6
Gene name phospholipase A2, group VI
Gene symbol Pla2g6
Other names/aliases BB112799
PNPLA9
iPLA(2)beta
iPLA2
iPLA2beta
Species Mus musculus
 Database cross references - Pla2g6
ExoCarta ExoCarta_53357
Entrez Gene 53357
UniProt P97819  
 Pla2g6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Pla2g6
Molecular Function
    calcium-independent phospholipase A2 activity GO:0047499 ISO
    protein kinase binding GO:0019901 ISO
    calmodulin binding GO:0005516 IEA
    ATP-dependent protein binding GO:0043008 ISO
    hydrolase activity GO:0016787 IEA
    phospholipase A2 activity GO:0004623 IEA
Biological Process
    positive regulation of protein phosphorylation GO:0001934 ISO
    lipid catabolic process GO:0016042 IEA
    positive regulation of ceramide biosynthetic process GO:2000304 ISO
    metabolic process GO:0008152 IEA
    urinary bladder smooth muscle contraction GO:0014832 ISO
    positive regulation of protein kinase C signaling GO:0090037 ISO
    response to endoplasmic reticulum stress GO:0034976 ISO
    memory GO:0007613 ISO
    positive regulation of exocytosis GO:0045921 ISO
    chemotaxis GO:0006935 IEA
    cardiolipin biosynthetic process GO:0032049 ISO
    positive regulation of release of cytochrome c from mitochondria GO:0090200 ISO
    positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 ISO
    positive regulation of vasodilation GO:0045909 ISO
    positive regulation of arachidonic acid secretion GO:0090238 ISO
    positive regulation of cytosolic calcium ion concentration GO:0007204 ISO
    regulation of store-operated calcium channel activity GO:1901339 ISO
    negative regulation of synaptic transmission, glutamatergic GO:0051967 ISO
    lipid metabolic process GO:0006629 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    cytoplasm GO:0005737 ISO
    microtubule organizing center GO:0005815 ISO
    mitochondrion GO:0005739 ISO
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Pla2g6 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Pla2g6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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