Gene description for Cadm1
Gene name cell adhesion molecule 1
Gene symbol Cadm1
Other names/aliases 2900073G06Rik
3100001I08Rik
AI987920
Bl2
Igsf4
Igsf4a
Necl2
RA175
RA175A
RA175B
RA175C
RA175N
ST17
SgIGSF
SynCam
Tslc1
Species Mus musculus
 Database cross references - Cadm1
ExoCarta ExoCarta_54725
Entrez Gene 54725
UniProt Q8R5M8  
 Cadm1 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Cadm1
Molecular Function
    cell adhesion molecule binding GO:0050839 ISO
    protein homodimerization activity GO:0042803 IDA
    protein binding GO:0005515 IPI
    receptor binding GO:0005102 ISO
    PDZ domain binding GO:0030165 IPI
Biological Process
    synapse assembly GO:0007416 IDA
    immune system process GO:0002376 IEA
    cell differentiation GO:0030154 IEA
    cell adhesion GO:0007155 IDA
    susceptibility to natural killer cell mediated cytotoxicity GO:0042271 ISO
    liver development GO:0001889 ISO
    multicellular organismal development GO:0007275 IEA
    apoptotic process GO:0006915 IEA
    unidimensional cell growth GO:0009826 IMP
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IDA
    positive regulation of natural killer cell mediated cytotoxicity GO:0045954 ISO
    detection of stimulus GO:0051606 ISO
    spermatogenesis GO:0007283 IEA
    calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338 IDA
    cell recognition GO:0008037 ISO
    positive regulation of cytokine secretion GO:0050715 ISO
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IDA
    bone development GO:0060348 IMP
Subcellular Localization
    varicosity GO:0043196 IDA
    synaptic vesicle GO:0008021 IDA
    basolateral plasma membrane GO:0016323 IDA
    plasma membrane GO:0005886 ISO
    cell junction GO:0030054 IEA
    cell body fiber GO:0070852 IDA
    neuron projection GO:0043005 ISO
    membrane GO:0016020 IEA
    dendrite GO:0030425 IDA
    cell-cell junction GO:0005911 IDA
    integral component of membrane GO:0016021 IEA
    synapse GO:0045202 IDA
    axon GO:0030424 IDA
    extracellular exosome GO:0070062 ISO
 Experiment description of studies that identified Cadm1 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cadm1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Cadm1 is involved
PathwayEvidenceSource
Adherens junctions interactions IEA Reactome
Nectin/Necl trans heterodimerization IEA Reactome





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