Gene description for Clcf1
Gene name cardiotrophin-like cytokine factor 1
Gene symbol Clcf1
Other names/aliases Bsf3
CLC
Species Mus musculus
 Database cross references - Clcf1
ExoCarta ExoCarta_56708
Entrez Gene 56708
UniProt Q9QZM3  
 Clcf1 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Clcf1
Molecular Function
    cytokine activity GO:0005125 ISO
    receptor binding GO:0005102 ISO
    protein heterodimerization activity GO:0046982 TAS
    ciliary neurotrophic factor receptor binding GO:0005127 TAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of ERK1 and ERK2 cascade GO:0070372 TAS
    JAK-STAT cascade GO:0007259 IDA
    positive regulation of B cell proliferation GO:0030890 IDA
    positive regulation of astrocyte differentiation GO:0048711 IDA
    positive regulation of corticotropin-releasing hormone secretion GO:0051466 TAS
    positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 ISO
    cell surface receptor signaling pathway GO:0007166 IDA
    regulation of inflammatory response GO:0050727 NAS
    negative regulation of motor neuron apoptotic process GO:2000672 NAS
    positive regulation of isotype switching to IgE isotypes GO:0048295 IDA
    negative regulation of neuron apoptotic process GO:0043524 NAS
    regulation of protein kinase B signaling GO:0051896 TAS
    positive regulation of cell proliferation GO:0008284 ISO
    B cell differentiation GO:0030183 IDA
    positive regulation of immunoglobulin production GO:0002639 IDA
    positive regulation of type 2 immune response GO:0002830 NAS
Subcellular Localization
    CNTFR-CLCF1 complex GO:0097059 ISO
    extracellular exosome GO:0070062 ISO
    CRLF-CLCF1 complex GO:0097058 TAS
    intracellular GO:0005622 TAS
    extracellular space GO:0005615 IEA
    extracellular region GO:0005576 ISO
 Experiment description of studies that identified Clcf1 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Clcf1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Clcf1 is involved
No pathways found





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