Gene description for PLEKHA4
Gene name pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
Gene symbol PLEKHA4
Other names/aliases PEPP1
Species Homo sapiens
 Database cross references - PLEKHA4
ExoCarta ExoCarta_57664
Vesiclepedia VP_57664
Entrez Gene 57664
HGNC 14339
MIM 607769
UniProt Q9H4M7  
 PLEKHA4 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for PLEKHA4
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IBA
    phosphatidylinositol-4,5-bisphosphate binding GO:0005546 IDA
    phosphatidylinositol-3-phosphate binding GO:0032266 IBA
    phosphatidylinositol-3-phosphate binding GO:0032266 IDA
    identical protein binding GO:0042802 IPI
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IBA
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 IDA
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IBA
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IDA
Biological Process
    positive regulation of canonical Wnt signaling pathway GO:0090263 IBA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IMP
    positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IBA
    positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IMP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 TAS
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA
    extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IDA
 Experiment description of studies that identified PLEKHA4 in exosomes
1
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PLEKHA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EIF3A 8661
Affinity Capture-MS Homo sapiens
2 MCMBP 79892
Affinity Capture-MS Homo sapiens
3 RALYL 138046
Affinity Capture-MS Homo sapiens
4 NPEPPS 9520
Affinity Capture-MS Homo sapiens
5 MIB1 57534
Affinity Capture-MS Homo sapiens
6 OXCT1 5019
Affinity Capture-MS Homo sapiens
7 ZNF24  
Affinity Capture-MS Homo sapiens
8 CARS2 79587
Affinity Capture-MS Homo sapiens
9 ZBTB11  
Affinity Capture-MS Homo sapiens
10 AATF  
Affinity Capture-MS Homo sapiens
11 HNRNPA0 10949
Affinity Capture-MS Homo sapiens
12 ZNF346  
Affinity Capture-MS Homo sapiens
13 EXOSC3 51010
Affinity Capture-MS Homo sapiens
14 TBC1D4  
Affinity Capture-MS Homo sapiens
15 TOP2B 7155
Affinity Capture-MS Homo sapiens
16 PM20D2 135293
Affinity Capture-MS Homo sapiens
17 KIAA2013 90231
Affinity Capture-MS Homo sapiens
18 CAP1 10487
Affinity Capture-MS Homo sapiens
19 CAND2 23066
Affinity Capture-MS Homo sapiens
20 GAK 2580
Affinity Capture-MS Homo sapiens
21 STK39 27347
Affinity Capture-MS Homo sapiens
22 SLC2A1 6513
Affinity Capture-MS Homo sapiens
23 NAA16 79612
Affinity Capture-MS Homo sapiens
24 UBE3A 7337
Affinity Capture-MS Homo sapiens
25 OXNAD1 92106
Affinity Capture-MS Homo sapiens
26 NHP2L1 4809
Affinity Capture-MS Homo sapiens
27 INTS1 26173
Affinity Capture-MS Homo sapiens
28 PARK7 11315
Affinity Capture-MS Homo sapiens
29 GCN1L1 10985
Affinity Capture-MS Homo sapiens
30 GFM2 84340
Affinity Capture-MS Homo sapiens
31 C16orf62 57020
Affinity Capture-MS Homo sapiens
32 LAMA2 3908
Affinity Capture-MS Homo sapiens
33 HOOK1  
Affinity Capture-MS Homo sapiens
34 SMG9 56006
Affinity Capture-MS Homo sapiens
35 RBM28 55131
Affinity Capture-MS Homo sapiens
36 DARS 1615
Affinity Capture-MS Homo sapiens
37 GFPT1 2673
Affinity Capture-MS Homo sapiens
38 ISYNA1 51477
Affinity Capture-MS Homo sapiens
39 RAF1 5894
Affinity Capture-MS Homo sapiens
40 CTDSPL2  
Affinity Capture-MS Homo sapiens
41 ACTR3 10096
Affinity Capture-MS Homo sapiens
42 PLCH1  
Affinity Capture-MS Homo sapiens
43 PEG10 23089
Affinity Capture-MS Homo sapiens
44 ERC1 23085
Affinity Capture-MS Homo sapiens
45 THTPA  
Affinity Capture-MS Homo sapiens
46 ABCD3 5825
Affinity Capture-MS Homo sapiens
47 KIAA1671  
Affinity Capture-MS Homo sapiens
48 ATAD5  
Affinity Capture-MS Homo sapiens
49 MARCH5  
Affinity Capture-MS Homo sapiens
50 RPS9 6203
Affinity Capture-MS Homo sapiens
51 CLPB 81570
Affinity Capture-MS Homo sapiens
52 NDUFA8 4702
Affinity Capture-MS Homo sapiens
53 TXNDC5 81567
Affinity Capture-MS Homo sapiens
54 SMC5 23137
Affinity Capture-MS Homo sapiens
55 NDUFAB1 4706
Affinity Capture-MS Homo sapiens
56 SLC30A9 10463
Affinity Capture-MS Homo sapiens
57 TUBB6 84617
Affinity Capture-MS Homo sapiens
58 KIF3A 11127
Affinity Capture-MS Homo sapiens
59 MRPL47 57129
Affinity Capture-MS Homo sapiens
60 TFRC 7037
Affinity Capture-MS Homo sapiens
61 FAM120A 23196
Affinity Capture-MS Homo sapiens
62 EMC1 23065
Affinity Capture-MS Homo sapiens
63 AGO2 27161
Affinity Capture-MS Homo sapiens
64 UNK  
Affinity Capture-MS Homo sapiens
65 MPI 4351
Affinity Capture-MS Homo sapiens
66 AURKA 6790
Affinity Capture-MS Homo sapiens
67 RCC2 55920
Affinity Capture-MS Homo sapiens
68 AP3M1 26985
Affinity Capture-MS Homo sapiens
69 HSP90AB4P 664618
Affinity Capture-MS Homo sapiens
70 TCP1 6950
Affinity Capture-MS Homo sapiens
71 UTP14A 10813
Affinity Capture-MS Homo sapiens
72 METTL15  
Affinity Capture-MS Homo sapiens
73 MCAT 27349
Affinity Capture-MS Homo sapiens
74 SRPRB 58477
Affinity Capture-MS Homo sapiens
75 TRAFD1  
Affinity Capture-MS Homo sapiens
76 CTBP1 1487
Affinity Capture-MS Homo sapiens
77 WDR89  
Affinity Capture-MS Homo sapiens
78 CSTF2 1478
Affinity Capture-MS Homo sapiens
79 RBM4B  
Affinity Capture-MS Homo sapiens
80 TUFM 7284
Affinity Capture-MS Homo sapiens
81 EEF1E1 9521
Affinity Capture-MS Homo sapiens
82 PYGB 5834
Affinity Capture-MS Homo sapiens
83 YRDC 79693
Affinity Capture-MS Homo sapiens
84 PIGT 51604
Affinity Capture-MS Homo sapiens
85 NOC4L 79050
Affinity Capture-MS Homo sapiens
86 RBM17 84991
Affinity Capture-MS Homo sapiens
87 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
88 RPS4XP21  
Affinity Capture-MS Homo sapiens
89 RBM33  
Affinity Capture-MS Homo sapiens
90 ENO1 2023
Affinity Capture-MS Homo sapiens
91 RFC4 5984
Affinity Capture-MS Homo sapiens
92 DPY19L3  
Affinity Capture-MS Homo sapiens
93 CUL2 8453
Affinity Capture-MS Homo sapiens
94 RRP1B 23076
Affinity Capture-MS Homo sapiens
95 YWHAEP7  
Affinity Capture-MS Homo sapiens
96 SEC61B 10952
Affinity Capture-MS Homo sapiens
97 IQGAP2 10788
Affinity Capture-MS Homo sapiens
98 SLC25A5 292
Affinity Capture-MS Homo sapiens
99 MAP2K7 5609
Affinity Capture-MS Homo sapiens
100 TRIP13 9319
Affinity Capture-MS Homo sapiens
101 CISD1 55847
Affinity Capture-MS Homo sapiens
102 HIST1H2AD 3013
Affinity Capture-MS Homo sapiens
103 HSPA5 3309
Affinity Capture-MS Homo sapiens
104 RBM39 9584
Affinity Capture-MS Homo sapiens
105 SMG7  
Affinity Capture-MS Homo sapiens
106 FAM134C 162427
Affinity Capture-MS Homo sapiens
107 HADHA 3030
Affinity Capture-MS Homo sapiens
108 SMARCE1 6605
Affinity Capture-MS Homo sapiens
109 DCAF7 10238
Affinity Capture-MS Homo sapiens
110 LRRC59 55379
Affinity Capture-MS Homo sapiens
111 LMNB1 4001
Affinity Capture-MS Homo sapiens
112 RFC5 5985
Affinity Capture-MS Homo sapiens
113 NPM3 10360
Affinity Capture-MS Homo sapiens
114 PRKCZ 5590
Affinity Capture-MS Homo sapiens
115 TMEM199  
Affinity Capture-MS Homo sapiens
116 MTAP 4507
Affinity Capture-MS Homo sapiens
117 HSPA14 51182
Affinity Capture-MS Homo sapiens
118 WDR55  
Affinity Capture-MS Homo sapiens
119 MRPL3  
Affinity Capture-MS Homo sapiens
120 ATAD3C 219293
Affinity Capture-MS Homo sapiens
121 MYO19  
Affinity Capture-MS Homo sapiens
122 AAAS 8086
Affinity Capture-MS Homo sapiens
123 KIAA1244  
Affinity Capture-MS Homo sapiens
124 EPRS 2058
Affinity Capture-MS Homo sapiens
125 EIF2S2 8894
Affinity Capture-MS Homo sapiens
126 TMEM263 90488
Affinity Capture-MS Homo sapiens
127 CDC42 998
Affinity Capture-MS Homo sapiens
128 STRAP 11171
Affinity Capture-MS Homo sapiens
129 TUBA4A 7277
Affinity Capture-MS Homo sapiens
130 FBXW11  
Affinity Capture-MS Homo sapiens
131 STAT1 6772
Affinity Capture-MS Homo sapiens
132 KIF1BP 26128
Affinity Capture-MS Homo sapiens
133 SHKBP1  
Affinity Capture-MS Homo sapiens
134 MBD2 8932
Affinity Capture-MS Homo sapiens
135 NUBP1 4682
Affinity Capture-MS Homo sapiens
136 ACTL6B  
Affinity Capture-MS Homo sapiens
137 ITPK1 3705
Affinity Capture-MS Homo sapiens
138 PARL  
Affinity Capture-MS Homo sapiens
139 AKT1 207
Affinity Capture-MS Homo sapiens
140 KCTD15 79047
Affinity Capture-MS Homo sapiens
141 UPF2 26019
Affinity Capture-MS Homo sapiens
142 SEPT2 4735
Affinity Capture-MS Homo sapiens
143 PPP2CB 5516
Affinity Capture-MS Homo sapiens
144 RRAGC 64121
Affinity Capture-MS Homo sapiens
145 YIF1B 90522
Affinity Capture-MS Homo sapiens
146 STUB1 10273
Affinity Capture-MS Homo sapiens
147 HK2 3099
Affinity Capture-MS Homo sapiens
148 DDX46 9879
Affinity Capture-MS Homo sapiens
149 NOSIP 51070
Affinity Capture-MS Homo sapiens
150 YBX1 4904
Affinity Capture-MS Homo sapiens
151 TUBGCP2 10844
Affinity Capture-MS Homo sapiens
152 IDH3B 3420
Affinity Capture-MS Homo sapiens
153 TMEM57  
Affinity Capture-MS Homo sapiens
154 HIST1H2AC 8334
Affinity Capture-MS Homo sapiens
155 MACF1 23499
Affinity Capture-MS Homo sapiens
156 MTA1 9112
Affinity Capture-MS Homo sapiens
157 TCERG1 10915
Affinity Capture-MS Homo sapiens
158 LARS2 23395
Affinity Capture-MS Homo sapiens
159 ARL8A 127829
Affinity Capture-MS Homo sapiens
160 DCTN2 10540
Affinity Capture-MS Homo sapiens
161 PTPN2 5771
Affinity Capture-MS Homo sapiens
162 TTK 7272
Affinity Capture-MS Homo sapiens
163 TRA2B 6434
Affinity Capture-MS Homo sapiens
164 PPL 5493
Affinity Capture-MS Homo sapiens
165 GTF2B 2959
Affinity Capture-MS Homo sapiens
166 ELMO2 63916
Affinity Capture-MS Homo sapiens
167 SSBP1 6742
Affinity Capture-MS Homo sapiens
168 PSMA1 5682
Affinity Capture-MS Homo sapiens
169 FAR1 84188
Affinity Capture-MS Homo sapiens
170 ERCC3  
Affinity Capture-MS Homo sapiens
171 WWP2 11060
Affinity Capture-MS Homo sapiens
172 CLASP1 23332
Affinity Capture-MS Homo sapiens
173 ALDH16A1 126133
Affinity Capture-MS Homo sapiens
174 PARS2 25973
Affinity Capture-MS Homo sapiens
175 EIF4B 1975
Affinity Capture-MS Homo sapiens
176 HNRNPLL 92906
Affinity Capture-MS Homo sapiens
177 RAD21 5885
Affinity Capture-MS Homo sapiens
178 ITPA 3704
Affinity Capture-MS Homo sapiens
179 ZNF768 79724
Affinity Capture-MS Homo sapiens
180 RPUSD3  
Affinity Capture-MS Homo sapiens
181 CLTA 1211
Affinity Capture-MS Homo sapiens
182 LIMD1 8994
Affinity Capture-MS Homo sapiens
183 MEAF6  
Affinity Capture-MS Homo sapiens
184 POLA1  
Affinity Capture-MS Homo sapiens
185 EI24  
Affinity Capture-MS Homo sapiens
186 ADGRE5 976
Affinity Capture-MS Homo sapiens
187 NUP85 79902
Affinity Capture-MS Homo sapiens
188 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
189 ZNF362  
Affinity Capture-MS Homo sapiens
190 PHF8  
Affinity Capture-MS Homo sapiens
191 PCYT1A 5130
Affinity Capture-MS Homo sapiens
192 SCAMP3 10067
Affinity Capture-MS Homo sapiens
193 BRI3BP 140707
Affinity Capture-MS Homo sapiens
194 NDUFS6  
Affinity Capture-MS Homo sapiens
195 EXOSC8  
Affinity Capture-MS Homo sapiens
196 CTNND1 1500
Affinity Capture-MS Homo sapiens
197 PSMD3 5709
Affinity Capture-MS Homo sapiens
198 CENPB 1059
Affinity Capture-MS Homo sapiens
199 LIG4 3981
Affinity Capture-MS Homo sapiens
200 MCM3 4172
Affinity Capture-MS Homo sapiens
201 CASP14 23581
Affinity Capture-MS Homo sapiens
202 PMPCA 23203
Affinity Capture-MS Homo sapiens
203 KATNAL1  
Affinity Capture-MS Homo sapiens
204 RPTOR 57521
Affinity Capture-MS Homo sapiens
205 RMI2  
Affinity Capture-MS Homo sapiens
206 RINT1 60561
Affinity Capture-MS Homo sapiens
207 LIN7B  
Affinity Capture-MS Homo sapiens
208 ARHGAP39  
Affinity Capture-MS Homo sapiens
209 TSC2 7249
Affinity Capture-MS Homo sapiens
210 PAWR 5074
Affinity Capture-MS Homo sapiens
211 CTBP2 1488
Affinity Capture-MS Homo sapiens
212 NACA 4666
Affinity Capture-MS Homo sapiens
213 MTPAP 55149
Affinity Capture-MS Homo sapiens
214 ARF3 377
Affinity Capture-MS Homo sapiens
215 TRIM33 51592
Affinity Capture-MS Homo sapiens
216 FAM21A 387680
Affinity Capture-MS Homo sapiens
217 URB2  
Affinity Capture-MS Homo sapiens
218 CAND1 55832
Affinity Capture-MS Homo sapiens
219 DIEXF  
Affinity Capture-MS Homo sapiens
220 SNRPF 6636
Affinity Capture-MS Homo sapiens
221 NDUFS2 4720
Affinity Capture-MS Homo sapiens
222 RPS3 6188
Affinity Capture-MS Homo sapiens
223 RPS18 6222
Affinity Capture-MS Homo sapiens
224 RWDD2B  
Affinity Capture-MS Homo sapiens
225 USO1 8615
Affinity Capture-MS Homo sapiens
226 SGPL1 8879
Affinity Capture-MS Homo sapiens
227 DPYSL2 1808
Affinity Capture-MS Homo sapiens
228 MYO5B 4645
Affinity Capture-MS Homo sapiens
229 H1FX 8971
Affinity Capture-MS Homo sapiens
230 COPS6 10980
Affinity Capture-MS Homo sapiens
231 DSCR3 10311
Affinity Capture-MS Homo sapiens
232 HARS2 23438
Affinity Capture-MS Homo sapiens
233 OSBP 5007
Affinity Capture-MS Homo sapiens
234 TIMM17B  
Affinity Capture-MS Homo sapiens
235 USE1 55850
Affinity Capture-MS Homo sapiens
236 ACTR1A 10121
Affinity Capture-MS Homo sapiens
237 MAP4K5 11183
Affinity Capture-MS Homo sapiens
238 KHDRBS1 10657
Affinity Capture-MS Homo sapiens
239 NUP93 9688
Affinity Capture-MS Homo sapiens
240 NARS 4677
Affinity Capture-MS Homo sapiens
241 RAB5B 5869
Affinity Capture-MS Homo sapiens
242 SUN2 25777
Affinity Capture-MS Homo sapiens
243 YIPF3 25844
Affinity Capture-MS Homo sapiens
244 TOMM40 10452
Affinity Capture-MS Homo sapiens
245 TIAL1 7073
Affinity Capture-MS Homo sapiens
246 FTSJ1 24140
Affinity Capture-MS Homo sapiens
247 TSN 7247
Affinity Capture-MS Homo sapiens
248 AP4E1  
Affinity Capture-MS Homo sapiens
249 GSK3B 2932
Affinity Capture-MS Homo sapiens
250 ERCC6L 54821
Affinity Capture-MS Homo sapiens
251 GAR1 54433
Affinity Capture-MS Homo sapiens
252 PES1 23481
Affinity Capture-MS Homo sapiens
253 TMEM201 199953
Affinity Capture-MS Homo sapiens
254 PAK1 5058
Affinity Capture-MS Homo sapiens
255 GTF2I 2969
Affinity Capture-MS Homo sapiens
256 PFKM 5213
Affinity Capture-MS Homo sapiens
257 RNF41  
Affinity Capture-MS Homo sapiens
258 SYMPK 8189
Affinity Capture-MS Homo sapiens
259 PPP5C 5536
Affinity Capture-MS Homo sapiens
260 TTC4  
Affinity Capture-MS Homo sapiens
261 DDX21 9188
Affinity Capture-MS Homo sapiens
262 RPL4 6124
Affinity Capture-MS Homo sapiens