Gene description for AKR1A1
Gene name aldo-keto reductase family 1, member A1 (aldehyde reductase)
Gene symbol AKR1A1
Other names/aliases -
Species Bos taurus
 Database cross references - AKR1A1
ExoCarta ExoCarta_618607
Entrez Gene 618607
UniProt Q3ZCJ2  
 AKR1A1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for AKR1A1
Molecular Function
    L-glucuronate reductase activity GO:0047939 IEA
    alcohol dehydrogenase (NADP+) activity GO:0008106 IEA
Biological Process
    D-glucuronate catabolic process GO:0042840 IEA
    aldehyde catabolic process GO:0046185 IEA
    L-ascorbic acid biosynthetic process GO:0019853 IEA
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    apical plasma membrane GO:0016324 IEA
    cytosol GO:0005829 IEA
    extracellular exosome GO:0070062 IEA
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified AKR1A1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for AKR1A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which AKR1A1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here