Gene description for Pdcd4
Gene name programmed cell death 4
Gene symbol Pdcd4
Other names/aliases Dug
Species Rattus norvegicus
 Database cross references - Pdcd4
ExoCarta ExoCarta_64031
Entrez Gene 64031
UniProt Q9JID1  
 Pdcd4 identified in exosomes derived from the following tissue/cell type
Pancreatic cancer cells 20124479    
Pancreatic cancer cells 20124479    
 Gene ontology annotations for Pdcd4
Molecular Function
    RNA binding GO:0003723 IEA
    molecular_function GO:0003674 ND
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 ISS
    negative regulation of JUN kinase activity GO:0043508 ISS
    apoptotic process GO:0006915 IEA
    negative regulation of apoptotic process GO:0043066 IDA
    cell aging GO:0007569 ISS
    regulation of protein metabolic process GO:0051246 IMP
    positive regulation of smooth muscle cell apoptotic process GO:0034393 IMP
Subcellular Localization
    nucleoplasm GO:0005654 ISO
    cellular_component GO:0005575 ND
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 ISS
    nucleus GO:0005634 ISS
 Experiment description of studies that identified Pdcd4 in exosomes
1
Experiment ID 92
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
RatRef-12 Microarray
FACS
Mass spectrometry [MALDI TOF]
2
Experiment ID 93
ISEV standards
EM
EV Biophysical techniques
HSP70|GAPDH
EV Cytosolic markers
CD9|CD151
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 20124479    
Organism Rattus norvegicus
Experiment description Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation.
Authors Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zoller M.
Journal name CR
Publication year 2010
Sample Pancreatic cancer cells
Sample name AS-Tspan8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14-1.17 g/mL
Molecules identified in the study Protein
mRNA
Methods used in the study RT-PCR
Western blotting
 Protein-protein interactions for Pdcd4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pdcd4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here