Gene description for SKOR2
Gene name SKI family transcriptional corepressor 2
Gene symbol SKOR2
Other names/aliases CORL2
FUSSEL18
Species Homo sapiens
 Database cross references - SKOR2
ExoCarta ExoCarta_652991
Entrez Gene 652991
HGNC 32695
UniProt Q2VWA4  
 SKOR2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SKOR2
Molecular Function
    transcription corepressor activity GO:0003714 ISS
    SMAD binding GO:0046332 IPI
Biological Process
    regulation of transcription, DNA-templated GO:0006355 NAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IBA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified SKOR2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SKOR2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SKOR2 is involved
No pathways found





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