Gene description for Steap3
Gene name STEAP family member 3
Gene symbol Steap3
Other names/aliases 1010001D01Rik
Tsap6
pHyde
Species Mus musculus
 Database cross references - Steap3
ExoCarta ExoCarta_68428
Vesiclepedia VP_68428
Entrez Gene 68428
UniProt Q8CI59  
 Steap3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Steap3
Molecular Function
    metal ion binding GO:0046872 IEA
    ferric-chelate reductase activity GO:0000293 IMP
    cupric reductase activity GO:0008823 IDA
    ferric-chelate reductase (NADPH) activity GO:0052851 IMP
    oxidoreductase activity GO:0016491 IEA
Biological Process
    exosomal secretion GO:1990182 IMP
    transport GO:0006810 IEA
    oxidation-reduction process GO:0055114 IMP
    iron ion homeostasis GO:0055072 IEA
    copper ion import GO:0015677 IMP
    positive regulation of apoptotic process GO:0043065 ISO
    iron ion transport GO:0006826 IMP
    apoptotic process GO:0006915 IEA
    positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902167 IMP
    protein secretion GO:0009306 ISS
    ferric iron import into cell GO:0097461 IMP
    ion transport GO:0006811 IEA
    cell cycle GO:0007049 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 IBA
    integral component of membrane GO:0016021 IEA
    endosome GO:0005768 IDA
    cell GO:0005623 IMP
    membrane GO:0016020 IEA
    multivesicular body GO:0005771 ISA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Steap3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Steap3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Steap3 is involved
PathwayEvidenceSource
Transferrin endocytosis and recycling IEA Reactome





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