Gene description for Gba
Gene name glucosidase, beta, acid
Gene symbol Gba
Other names/aliases -
Species Rattus norvegicus
 Database cross references - Gba
ExoCarta ExoCarta_684536
Entrez Gene 684536
 Gba identified in exosomes derived from the following tissue/cell type
Reticulocytes 21828046    
 Gene ontology annotations for Gba
Molecular Function
    receptor binding GO:0005102 ISO
    glucosylceramidase activity GO:0004348 ISO
Biological Process
    sphingosine biosynthetic process GO:0046512 ISO
    response to estrogen GO:0043627 IDA
    response to thyroid hormone GO:0097066 IDA
    carbohydrate metabolic process GO:0005975 IEA
    regulation of water loss via skin GO:0033561 IMP
    cellular response to tumor necrosis factor GO:0071356 ISO
    response to glucocorticoid GO:0051384 IDA
    response to pH GO:0009268 IDA
    termination of signal transduction GO:0023021 ISO
    positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 ISO
    skin morphogenesis GO:0043589 IMP
    response to testosterone GO:0033574 IDA
    positive regulation of protein dephosphorylation GO:0035307 ISO
    negative regulation of MAP kinase activity GO:0043407 ISO
    negative regulation of interleukin-6 production GO:0032715 ISO
    glucosylceramide catabolic process GO:0006680 ISO
    ceramide biosynthetic process GO:0046513 ISO
Subcellular Localization
    extracellular exosome GO:0070062 ISO
    lysosomal membrane GO:0005765 ISO
    lysosomal lumen GO:0043202 ISO
 Experiment description of studies that identified Gba in exosomes
1
Experiment ID 96
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP90|HSC70
EV Cytosolic markers
MHCI
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [Orbitrap]
PubMed ID 21828046    
Organism Rattus norvegicus
Experiment description The proteo-lipidic composition of exosomes changes during reticulocyte maturation.
Authors Carayon K, Chaoui K, Ronzier E, Lazar I, Bertrand-Michel J, Roques V, Balor S, Terce F, Lopez A, Salome L, Joly E.
Journal name JBC
Publication year 2011
Sample Reticulocytes
Sample name Reticulocytes - D2 Rep 2
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.16-1.21 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Mass spectrometry [QSTAR]
Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for Gba
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Gba is involved
No pathways found





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