Gene description for Lrrc16a
Gene name leucine rich repeat containing 16A
Gene symbol Lrrc16a
Other names/aliases 1110037D04Rik
AI425970
CARMIL
D130057M20
Lrrc16
Species Mus musculus
 Database cross references - Lrrc16a
ExoCarta ExoCarta_68732
Vesiclepedia VP_68732
Entrez Gene 68732
UniProt Q6EDY6  
 Lrrc16a identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Lrrc16a
Molecular Function
    protein complex binding GO:0032403 ISO
Biological Process
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of lamellipodium organization GO:1902745 ISO
    urate metabolic process GO:0046415 ISO
    lamellipodium assembly GO:0030032 ISO
    cell migration GO:0016477 ISO
    negative regulation of barbed-end actin filament capping GO:2000813 IMP
    positive regulation of stress fiber assembly GO:0051496 ISO
    positive regulation of actin filament polymerization GO:0030838 IMP
    ruffle organization GO:0031529 ISO
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 ISO
    barbed-end actin filament uncapping GO:0051638 IMP
Subcellular Localization
    nucleus GO:0005634 ISO
    filamentous actin GO:0031941 IDA
    lamellipodium GO:0030027 ISO
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Lrrc16a in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Lrrc16a
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Lrrc16a is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production IEA Reactome





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