Gene description for Foxk2
Gene name forkhead box K2
Gene symbol Foxk2
Other names/aliases 1110054H05Rik
5730434B08Rik
6230415M23Rik
ILF
Ilf1
Species Mus musculus
 Database cross references - Foxk2
ExoCarta ExoCarta_68837
Entrez Gene 68837
UniProt Q3UCQ1  
 Foxk2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Foxk2
Molecular Function
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 ISO
    magnesium ion binding GO:0000287 ISO
    sequence-specific DNA binding GO:0043565 ISO
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    metal ion binding GO:0046872 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 ISO
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IBA
    DNA binding GO:0003677 IEA
Biological Process
    regulation of transcription from RNA polymerase II promoter GO:0006357 IBA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    transcription, DNA-templated GO:0006351 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    transcription from RNA polymerase II promoter GO:0006366 IBA
    anatomical structure morphogenesis GO:0009653 IBA
    cell differentiation GO:0030154 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 ISO
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Foxk2 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Foxk2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Foxk2 is involved
No pathways found





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