Gene description for Atp6ap2
Gene name ATPase, H+ transporting, lysosomal accessory protein 2
Gene symbol Atp6ap2
Other names/aliases (P)RR
5730403E06Rik
APT6M8-9
ATP6M8-9
Atp6ip2
M8-9
Species Mus musculus
 Database cross references - Atp6ap2
ExoCarta ExoCarta_70495
Entrez Gene 70495
UniProt Q9CYN9  
 Atp6ap2 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
 Gene ontology annotations for Atp6ap2
Molecular Function
    receptor activity GO:0004872 IEA
    aspartic-type endopeptidase activity GO:0004190 ISO
    enzyme binding GO:0019899 ISO
Biological Process
    regulation of MAPK cascade GO:0043408 ISO
    head morphogenesis GO:0060323 ISO
    angiotensin maturation GO:0002003 ISO
    eye pigmentation GO:0048069 ISO
    rostrocaudal neural tube patterning GO:0021903 ISO
    positive regulation of Wnt signaling pathway GO:0030177 ISO
    positive regulation of transforming growth factor beta1 production GO:0032914 ISO
Subcellular Localization
    neuron projection GO:0043005 ISO
    extracellular exosome GO:0070062 ISO
    external side of plasma membrane GO:0009897 ISO
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
    cell body GO:0044297 ISO
 Experiment description of studies that identified Atp6ap2 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Atp6ap2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Atp6ap2 is involved
PathwayEvidenceSource
Metabolism of Angiotensinogen to Angiotensins IEA Reactome





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