Gene description for Crot
Gene name carnitine O-octanoyltransferase
Gene symbol Crot
Other names/aliases 1200003H03Rik
Species Mus musculus
 Database cross references - Crot
ExoCarta ExoCarta_74114
Entrez Gene 74114
UniProt Q9DC50  
 Crot identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Crot
Molecular Function
    transferase activity, transferring acyl groups GO:0016746 IEA
    receptor binding GO:0005102 ISO
    carnitine O-octanoyltransferase activity GO:0008458 ISO
    transferase activity GO:0016740 IEA
Biological Process
    response to drug GO:0042493 ISO
    fatty acid metabolic process GO:0006631 ISO
    transport GO:0006810 IEA
    fatty acid transport GO:0015908 IDA
    fatty acid beta-oxidation GO:0006635 ISO
    carnitine metabolic process GO:0009437 IDA
    generation of precursor metabolites and energy GO:0006091 ISO
    coenzyme A metabolic process GO:0015936 IDA
    medium-chain fatty acid metabolic process GO:0051791 ISO
    lipid metabolic process GO:0006629 IEA
Subcellular Localization
    mitochondrion GO:0005739 IDA
    intracellular membrane-bounded organelle GO:0043231 ISO
    peroxisome GO:0005777 ISO
 Experiment description of studies that identified Crot in exosomes
1
Experiment ID 264
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th2 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Crot
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Crot is involved
PathwayEvidenceSource
Beta-oxidation of pristanoyl-CoA IEA Reactome





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