Gene description for Apobec3
Gene name apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3
Gene symbol Apobec3
Other names/aliases Arp3
BC003314
Cem15
Rfv3
Species Mus musculus
 Database cross references - Apobec3
ExoCarta ExoCarta_80287
Vesiclepedia VP_80287
Entrez Gene 80287
 Apobec3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Apobec3
Molecular Function
    N-cyclopropylmelamine deaminase activity GO:0034547 IEA
    deoxycytidine deaminase activity GO:0047844 ISO
    GTP cyclohydrolase activity GO:0003933 IEA
    protein binding GO:0005515 IPI
    catalytic activity GO:0003824 IEA
    metal ion binding GO:0046872 IEA
    tRNA-specific adenosine-37 deaminase activity GO:0043829 IEA
    N-cyclopropylammelide alkylamino hydrolase activity GO:0034549 IEA
    archaeal-specific GTP cyclohydrolase activity GO:0044682 IEA
    tRNA-specific adenosine-34 deaminase activity GO:0052717 IEA
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0016814 IEA
    tRNA-specific adenosine deaminase activity GO:0008251 IEA
    poly(A) RNA binding GO:0044822 ISO
    N-cyclopropylammeline deaminase activity GO:0034548 IEA
    hydrolase activity GO:0016787 IEA
    2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity GO:0043723 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    immune system process GO:0002376 IEA
    defense response to virus GO:0051607 ISO
    innate immune response GO:0045087 IEA
    hematopoietic progenitor cell differentiation GO:0002244 IGI
    negative regulation of viral genome replication GO:0045071 IDA
    metabolic process GO:0008152 ISO
    negative regulation of transposition GO:0010529 ISO
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Apobec3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Apobec3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Apobec3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here