Gene description for Slc16a3
Gene name solute carrier family 16 (monocarboxylic acid transporters), member 3
Gene symbol Slc16a3
Other names/aliases Mct3
Mct4
Species Mus musculus
 Database cross references - Slc16a3
ExoCarta ExoCarta_80879
Entrez Gene 80879
UniProt P57787  
 Slc16a3 identified in exosomes derived from the following tissue/cell type
Macrophages 23658846    
Macrophages 23658846    
Macrophages 23658846    
 Gene ontology annotations for Slc16a3
Molecular Function
    lactate transmembrane transporter activity GO:0015129 IBA
    symporter activity GO:0015293 IEA
    poly(A) RNA binding GO:0044822 ISO
    monocarboxylic acid transmembrane transporter activity GO:0008028 IEA
Biological Process
    monocarboxylic acid transport GO:0015718 IEA
    transmembrane transport GO:0055085 IEA
    transport GO:0006810 IEA
    plasma membrane lactate transport GO:0035879 ISO
Subcellular Localization
    plasma membrane GO:0005886 ISO
    actin cytoskeleton GO:0015629 ISO
    nuclear membrane GO:0031965 ISO
    integral component of plasma membrane GO:0005887 IBA
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Slc16a3 in exosomes
1
Experiment ID 214
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Leishmania-infected-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 215
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name LPS-treated-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 216
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23658846    
Organism Mus musculus
Experiment description Immunomodulatory impact of leishmania-induced macrophage exosomes: a comparative proteomic and functional analysis.
Authors Hassani K, Olivier M.
Journal name PLoS Negl Trop Dis
Publication year 2013
Sample Macrophages
Sample name Normal-Macrophage (J774A.1)
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Filtration
Protease inhibitors
Sucrose density gradient
Filtration
Ultracentrifugation
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Slc16a3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc16a3 is involved
PathwayEvidenceSource
Basigin interactions IEA Reactome
Proton-coupled monocarboxylate transport IEA Reactome
Pyruvate metabolism IEA Reactome





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