Gene description for Glce
Gene name glucuronyl C5-epimerase
Gene symbol Glce
Other names/aliases 1110017N23Rik
AI747411
C130034A12Rik
Hsepi
Species Mus musculus
 Database cross references - Glce
ExoCarta ExoCarta_93683
Entrez Gene 93683
UniProt Q9EPS3  
 Glce identified in exosomes derived from the following tissue/cell type
Neural stem cells 25242146    
 Gene ontology annotations for Glce
Molecular Function
    racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016857 IMP
    isomerase activity GO:0016853 IEA
    heparosan-N-sulfate-glucuronate 5-epimerase activity GO:0047464 ISO
    UDP-glucuronate 5'-epimerase activity GO:0050379 ISS
Biological Process
    glycosaminoglycan biosynthetic process GO:0006024 IEA
    heparin biosynthetic process GO:0030210 IDA
    heparan sulfate proteoglycan biosynthetic process GO:0015012 ISO
Subcellular Localization
    membrane GO:0016020 IEA
    Golgi apparatus GO:0005794 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified Glce in exosomes
1
Experiment ID 263
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25242146    
Organism Mus musculus
Experiment description Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells
Authors Chiara Cossetti, Nunzio Iraci, Tim R. Mercer, Tommaso Leonardi, Emanuele Alpi, Denise Drago, Clara Alfaro-Cervello, Harpreet K. Saini, Matthew P. Davis, Julia Schaeffer, Beatriz Vega, Matilde Stefanini, CongJian Zhao, Werner Muller, Jose Manuel Garcia-Verdugo, Suresh Mathivanan, Angela Bachi, Anton J. Enright, John S. Mattick, Stefano Pluchino
Journal name Molecular Cell
Publication year 2014
Sample Neural stem cells
Sample name NPCs - Th1 treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.20 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Glce
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Glce is involved
PathwayEvidenceSource
HS-GAG biosynthesis IEA Reactome





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