Gene description for CORO2B
Gene name coronin, actin binding protein, 2B
Gene symbol CORO2B
Other names/aliases CLIPINC
Species Homo sapiens
 Database cross references - CORO2B
ExoCarta ExoCarta_10391
Vesiclepedia VP_10391
Entrez Gene 10391
HGNC 2256
MIM 605002
UniProt Q9UQ03  
 CORO2B identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CORO2B
Molecular Function
    actin binding GO:0003779 NAS
    protein binding GO:0005515 IPI
    vinculin binding GO:0017166 IPI
    actin filament binding GO:0051015 IBA
    talin binding GO:1990147 IDA
Biological Process
    regulation of glomerular filtration GO:0003093 IEA
    negative regulation of cell-substrate adhesion GO:0010812 IDA
    actin cytoskeleton organization GO:0030036 NAS
    regulation of actin cytoskeleton organization GO:0032956 IDA
    focal adhesion assembly GO:0048041 IEA
    negative regulation of stress fiber assembly GO:0051497 IEA
    regulation of cellular response to stress GO:0080135 IDA
    negative regulation of establishment of protein localization GO:1904950 IDA
    positive regulation of establishment of protein localization GO:1904951 IDA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    focal adhesion GO:0005925 IDA
    actin cytoskeleton GO:0015629 NAS
    membrane GO:0016020 NAS
 Experiment description of studies that identified CORO2B in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CORO2B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RNF219  
Affinity Capture-MS Homo sapiens
2 APPBP2  
Two-hybrid Homo sapiens
3 ARHGEF25 115557
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ACACA 31
Negative Genetic Homo sapiens
5 MYC  
Affinity Capture-MS Homo sapiens
6 CORO2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TSC22D1 8848
Two-hybrid Homo sapiens
8 VCL 7414
Affinity Capture-Western Homo sapiens
9 SHC1 6464
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PRKG1 5592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 KLHL20  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CORO2B is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here