Gene description for Camk2d
Gene name calcium/calmodulin-dependent protein kinase II, delta
Gene symbol Camk2d
Other names/aliases 2810011D23Rik
8030469K03Rik
CaMK II
[d]-CaMKII
Species Mus musculus
 Database cross references - Camk2d
ExoCarta ExoCarta_108058
Vesiclepedia VP_108058
Entrez Gene 108058
UniProt Q6PHZ2  
 Camk2d identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Camk2d
Molecular Function
    protein kinase activity GO:0004672 ISO
    protein serine/threonine kinase activity GO:0004674 IDA
    protein serine/threonine kinase activity GO:0004674 IMP
    protein serine/threonine kinase activity GO:0004674 ISO
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IBA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 IDA
    calcium/calmodulin-dependent protein kinase activity GO:0004683 ISO
    calcium/calmodulin-dependent protein kinase activity GO:0004683 ISS
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 IEA
    calmodulin binding GO:0005516 ISO
    ATP binding GO:0005524 IEA
    sodium channel inhibitor activity GO:0019871 ISO
    titin binding GO:0031432 ISO
    identical protein binding GO:0042802 ISO
    protein homodimerization activity GO:0042803 ISO
    transmembrane transporter binding GO:0044325 IPI
    transmembrane transporter binding GO:0044325 ISO
    nitric-oxide synthase binding GO:0050998 ISO
    protein serine kinase activity GO:0106310 IEA
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IMP
    response to hypoxia GO:0001666 ISO
    regulation of sodium ion transport GO:0002028 IDA
    regulation of membrane depolarization GO:0003254 ISO
    protein phosphorylation GO:0006468 ISO
    protein phosphorylation GO:0006468 ISS
    calcium ion transport GO:0006816 IDA
    calcium ion transport GO:0006816 IMP
    positive regulation of cardiac muscle hypertrophy GO:0010613 ISO
    positive regulation of cardiac muscle hypertrophy GO:0010613 ISS
    regulation of cell communication by electrical coupling GO:0010649 ISO
    positive regulation of cardiac muscle cell apoptotic process GO:0010666 ISO
    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 ISO
    positive regulation of G2/M transition of mitotic cell cycle GO:0010971 ISO
    positive regulation of smooth muscle cell migration GO:0014911 ISO
    peptidyl-serine phosphorylation GO:0018105 IDA
    peptidyl-serine phosphorylation GO:0018105 ISO
    peptidyl-threonine phosphorylation GO:0018107 ISO
    peptidyl-threonine phosphorylation GO:0018107 ISS
    intracellular potassium ion homeostasis GO:0030007 ISO
    endoplasmic reticulum calcium ion homeostasis GO:0032469 ISO
    positive regulation of Rac protein signal transduction GO:0035022 ISO
    protein autophosphorylation GO:0046777 IMP
    protein autophosphorylation GO:0046777 ISO
    regulation of neuronal synaptic plasticity GO:0048168 IBA
    relaxation of cardiac muscle GO:0055119 ISO
    relaxation of cardiac muscle GO:0055119 ISS
    cardiac muscle contraction GO:0060048 IDA
    regulation of cellular localization GO:0060341 ISO
    regulation of cellular localization GO:0060341 ISS
    cell growth involved in cardiac muscle cell development GO:0061049 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    cardiac muscle cell contraction GO:0086003 ISO
    cardiac muscle cell contraction GO:0086003 ISS
    regulation of cardiac muscle cell action potential GO:0098901 ISO
    regulation of relaxation of cardiac muscle GO:1901897 IGI
    regulation of relaxation of cardiac muscle GO:1901897 ISO
    negative regulation of sodium ion transmembrane transport GO:1902306 ISO
    regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514 ISO
    regulation of protein localization to plasma membrane GO:1903076 IBA
    regulation of protein localization to plasma membrane GO:1903076 ISO
    positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 ISO
    positive regulation of DNA biosynthetic process GO:2000573 ISO
    negative regulation of sodium ion transmembrane transporter activity GO:2000650 ISO
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    calcium- and calmodulin-dependent protein kinase complex GO:0005954 ISO
    postsynaptic density GO:0014069 IBA
    intercalated disc GO:0014704 IDA
    T-tubule GO:0030315 IDA
    neuromuscular junction GO:0031594 IDA
    protein-containing complex GO:0032991 ISO
    sarcoplasmic reticulum membrane GO:0033017 IEA
    neuron projection GO:0043005 IBA
    neuronal cell body GO:0043025 IDA
    axon initial segment GO:0043194 IDA
    perinuclear region of cytoplasm GO:0048471 ISO
    cochlear hair cell ribbon synapse GO:0098683 IDA
    postsynaptic cytosol GO:0099524 IDA
 Experiment description of studies that identified Camk2d in sEVs
1
Experiment ID 907
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Camk2d
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Lnx1  
Affinity Capture-MS Mus musculus
2 Mettl21e  
Affinity Capture-MS Mus musculus
3 Tnik  
Affinity Capture-MS Mus musculus
4 SNCA 6622
Affinity Capture-MS Homo sapiens
5 Fmr1  
Affinity Capture-MS Mus musculus
6 Foxp3  
Affinity Capture-MS Mus musculus
7 Kctd13  
Affinity Capture-MS Mus musculus
8 Agap2  
Affinity Capture-MS Mus musculus
9 Kalrn  
Affinity Capture-MS Mus musculus
10 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
11 Shank3  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
12 Atg16l1  
Affinity Capture-MS Mus musculus
13 Hdac4  
Reconstituted Complex Mus musculus
14 Tsc1  
Affinity Capture-MS Mus musculus
15 Ttc5  
Co-fractionation Mus musculus
16 Flii  
Co-fractionation Mus musculus
17 Mecp2  
Affinity Capture-MS Mus musculus
18 Ywhaz 22631
Affinity Capture-MS Mus musculus
19 Dlgap1  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
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