Gene description for Gusb
Gene name glucuronidase, beta
Gene symbol Gusb
Other names/aliases AI747421
Gur
Gus
Gus-r
Gus-s
Gus-t
Gus-u
Gut
asd
g
Species Mus musculus
 Database cross references - Gusb
ExoCarta ExoCarta_110006
Vesiclepedia VP_110006
Entrez Gene 110006
UniProt P12265  
 Gusb identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Gusb
Molecular Function
    beta-glucuronidase activity GO:0004566 IBA
    beta-glucuronidase activity GO:0004566 IDA
    beta-glucuronidase activity GO:0004566 IMP
    beta-glucuronidase activity GO:0004566 ISO
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 IEA
    signaling receptor binding GO:0005102 ISO
    hydrolase activity GO:0016787 IDA
    protein domain specific binding GO:0019904 IEA
    protein domain specific binding GO:0019904 ISO
    carbohydrate binding GO:0030246 IBA
    carbohydrate binding GO:0030246 ISO
Biological Process
    carbohydrate metabolic process GO:0005975 IDA
    heparan sulfate proteoglycan catabolic process GO:0030200 IMP
    chondroitin sulfate catabolic process GO:0030207 IMP
    hyaluronan catabolic process GO:0030214 IMP
    hyaluronan catabolic process GO:0030214 ISO
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular space GO:0005615 ISO
    lysosome GO:0005764 IDA
    lysosome GO:0005764 IDA
    endoplasmic reticulum GO:0005783 IEA
    lysosomal lumen GO:0043202 IDA
    lysosomal lumen GO:0043202 IMP
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Gusb in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Gusb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 P4htm  
Co-fractionation Mus musculus
2 Sumf1  
Co-fractionation Mus musculus
3 Fkbp9  
Co-fractionation Mus musculus
4 Txndc5 105245
Co-fractionation Mus musculus
5 Tmx3  
Co-fractionation Mus musculus
View the network image/svg+xml



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