Gene description for KATNA1
Gene name katanin p60 (ATPase containing) subunit A 1
Gene symbol KATNA1
Other names/aliases -
Species Homo sapiens
 Database cross references - KATNA1
ExoCarta ExoCarta_11104
Vesiclepedia VP_11104
Entrez Gene 11104
HGNC 6216
MIM 606696
UniProt O75449  
 KATNA1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for KATNA1
Molecular Function
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    microtubule binding GO:0008017 IDA
    microtubule severing ATPase activity GO:0008568 IDA
    isomerase activity GO:0016853 IEA
    ATP hydrolysis activity GO:0016887 IBA
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    cytoplasmic microtubule organization GO:0031122 IDA
    cytoplasmic microtubule organization GO:0031122 NAS
    microtubule severing GO:0051013 IBA
    cell division GO:0051301 IEA
Subcellular Localization
    spindle pole GO:0000922 IDA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IEA
    spindle GO:0005819 IDA
    microtubule GO:0005874 IEA
    katanin complex GO:0008352 IPI
    microtubule cytoskeleton GO:0015630 IBA
    microtubule cytoskeleton GO:0015630 NAS
    midbody GO:0030496 IDA
    mitotic spindle pole GO:0097431 IDA
 Experiment description of studies that identified KATNA1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for KATNA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STUB1 10273
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 PAFAH1B1 5048
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 NCKAP5L  
Affinity Capture-MS Homo sapiens
5 LATS1  
Affinity Capture-MS Homo sapiens
6 ASB3 51130
Affinity Capture-MS Homo sapiens
7 MAPT  
Affinity Capture-MS Homo sapiens
8 KATNBL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 SLC30A7 148867
Affinity Capture-MS Homo sapiens
11 ARHGAP39  
Affinity Capture-MS Homo sapiens
12 ENOPH1 58478
Affinity Capture-MS Homo sapiens
13 USP1 7398
Affinity Capture-MS Homo sapiens
14 CCT2 10576
Affinity Capture-MS Homo sapiens
15 Katnb1  
Two-hybrid Mus musculus
16 SNX27 81609
Affinity Capture-MS Homo sapiens
17 CAMSAP3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
18 VPRBP 9730
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
19 GOLT1B 51026
Affinity Capture-MS Homo sapiens
20 LDLRAD4  
Affinity Capture-MS Homo sapiens
21 PFDN1 5201
Affinity Capture-MS Homo sapiens
22 SRPR 6734
Affinity Capture-MS Homo sapiens
23 CUL3 8452
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
24 HSPA1A 3303
Affinity Capture-Western Homo sapiens
25 MAPK12  
Co-fractionation Homo sapiens
26 SRPRB 58477
Affinity Capture-MS Homo sapiens
27 CAMSAP2  
Proximity Label-MS Homo sapiens
28 CLU 1191
Two-hybrid Homo sapiens
29 SRSF2 6427
Affinity Capture-MS Homo sapiens
30 PNMA2  
Affinity Capture-MS Homo sapiens
31 ACACA 31
Positive Genetic Homo sapiens
32 SRSF3 6428
Affinity Capture-MS Homo sapiens
33 APP 351
Reconstituted Complex Homo sapiens
34 SPTBN1 6711
Affinity Capture-MS Homo sapiens
35 CCT5 22948
Affinity Capture-MS Homo sapiens
36 DYNC1H1 1778
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
37 KLHL42  
Affinity Capture-Western Homo sapiens
38 Ndel1  
Two-hybrid Mus musculus
39 INPP5K 51763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 SOAT1 6646
Affinity Capture-MS Homo sapiens
41 PFDN2 5202
Affinity Capture-MS Homo sapiens
42 LACRT 90070
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 USP47 55031
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 UBR5 51366
Affinity Capture-Western Homo sapiens
45 OGT 8473
Reconstituted Complex Homo sapiens
46 DDB1 1642
Affinity Capture-Western Homo sapiens
47 CCDC88C 440193
Affinity Capture-MS Homo sapiens
48 AKR7A2 8574
Affinity Capture-MS Homo sapiens
49 NDEL1 81565
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
50 SORBS3 10174
Affinity Capture-MS Homo sapiens
51 DYRK2 8445
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
52 PSMD9 5715
Affinity Capture-MS Homo sapiens
53 PFDN4 5203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
55 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
56 Dync1h1 13424
Two-hybrid Mus musculus
57 RPUSD2  
Co-fractionation Homo sapiens
58 CAPN1 823
Affinity Capture-MS Homo sapiens
59 ARIH1 25820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 KATNB1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 RTEL1 51750
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KATNA1 is involved
No pathways found





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