Gene description for PRKCDBP
Gene name protein kinase C, delta binding protein
Gene symbol PRKCDBP
Other names/aliases CAVIN3
HSRBC
SRBC
cavin-3
Species Homo sapiens
 Database cross references - PRKCDBP
ExoCarta ExoCarta_112464
Vesiclepedia VP_112464
Entrez Gene 112464
HGNC 9400
UniProt Q969G5  
 PRKCDBP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Mesenchymal stem cells 36408942    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for PRKCDBP
Molecular Function
    protein kinase C binding GO:0005080 IBA
    protein binding GO:0005515 IPI
Biological Process
    cortical actin cytoskeleton organization GO:0030866 IEA
    circadian regulation of gene expression GO:0032922 ISS
    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA
    negative regulation of fermentation GO:1901003 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IEA
    caveola GO:0005901 IBA
    caveola GO:0005901 IDA
    protein-containing complex GO:0032991 IDA
 Experiment description of studies that identified PRKCDBP in sEVs
1
Experiment ID 489
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 488
MISEV standards
✔ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✔ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔ Enriched markers
✔ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRKCDBP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SSR4 6748
Co-fractionation Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
3 PTBP3 9991
Co-fractionation Homo sapiens
4 Tmed2 56334
Affinity Capture-MS Mus musculus
5 TMPO 7112
Affinity Capture-MS Homo sapiens
6 SPTAN1 6709
Co-fractionation Homo sapiens
7 KIF14 9928
Affinity Capture-MS Homo sapiens
8 ILF3 3609
Co-fractionation Homo sapiens
9 RPS3A 6189
Co-fractionation Homo sapiens
10 VAPA 9218
Affinity Capture-MS Homo sapiens
11 TMEM184A  
Affinity Capture-MS Homo sapiens
12 XPO1 7514
Affinity Capture-MS Homo sapiens
13 RPS26 6231
Co-fractionation Homo sapiens
14 MAGEA11  
Two-hybrid Homo sapiens
15 CCT2 10576
Co-fractionation Homo sapiens
16 GOLGA6L9  
Two-hybrid Homo sapiens
17 CALU 813
Co-fractionation Homo sapiens
18 TMEM63B 55362
Affinity Capture-MS Homo sapiens
19 NUP62 23636
Two-hybrid Homo sapiens
20 Bmpr1a  
Affinity Capture-MS Mus musculus
21 Chmp4b 75608
Affinity Capture-MS Mus musculus
22 GOLT1B 51026
Affinity Capture-MS Homo sapiens
23 Rmdn3  
Affinity Capture-MS Mus musculus
24 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
25 KIF20A 10112
Affinity Capture-MS Homo sapiens
26 STBD1 8987
Affinity Capture-MS Homo sapiens
27 UBC 7316
Reconstituted Complex Homo sapiens
28 Set 56086
Affinity Capture-MS Mus musculus
29 NENF 29937
Co-fractionation Homo sapiens
30 TMEM147 10430
Affinity Capture-MS Homo sapiens
31 AGPAT3 56894
Affinity Capture-MS Homo sapiens
32 MRPL49 740
Co-fractionation Homo sapiens
33 MTHFD1 4522
Co-fractionation Homo sapiens
34 SFXN1 94081
Co-fractionation Homo sapiens
35 GPRASP2  
Two-hybrid Homo sapiens
36 SPTBN1 6711
Co-fractionation Homo sapiens
37 MMGT1 93380
Affinity Capture-MS Homo sapiens
38 ILF2 3608
Co-fractionation Homo sapiens
39 TUFM 7284
Co-fractionation Homo sapiens
40 SUN2 25777
Affinity Capture-MS Homo sapiens
41 TMEM43 79188
Affinity Capture-MS Homo sapiens
42 MRFAP1L1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
43 PC 5091
Co-fractionation Homo sapiens
44 MYC  
Affinity Capture-MS Homo sapiens
45 FGFR1OP2  
Affinity Capture-MS Homo sapiens
46 CEP70  
Two-hybrid Homo sapiens
47 REEP1  
Affinity Capture-MS Homo sapiens
48 PRC1 9055
Affinity Capture-MS Homo sapiens
49 CKAP5 9793
Affinity Capture-MS Homo sapiens
50 CFAP97  
Affinity Capture-MS Homo sapiens
51 RAB7A 7879
Affinity Capture-MS Homo sapiens
52 TPM4 7171
Co-fractionation Homo sapiens
53 MRFAP1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
54 MRPL23 6150
Co-fractionation Homo sapiens
55 CDH2 1000
Co-fractionation Homo sapiens
56 Flot1 14251
Affinity Capture-MS Mus musculus
57 FBXW7  
Affinity Capture-MS Homo sapiens
58 YIPF5 81555
Affinity Capture-MS Homo sapiens
59 MATR3 9782
Co-fractionation Homo sapiens
60 PTRF 284119
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
61 RAB5C 5878
Affinity Capture-MS Homo sapiens
62 Kctd5  
Affinity Capture-MS Mus musculus
63 Coro1c 23790
Affinity Capture-MS Mus musculus
64 Ptpn23 104831
Affinity Capture-MS Mus musculus
65 RPL21 6144
Co-fractionation Homo sapiens
66 C1qbp 12261
Affinity Capture-MS Mus musculus
67 Sept9  
Affinity Capture-MS Mus musculus
68 Flot2 14252
Affinity Capture-MS Mus musculus
69 BRCA1 672
Reconstituted Complex Homo sapiens
70 RPS16 6217
Co-fractionation Homo sapiens
71 SARS2 54938
Co-fractionation Homo sapiens
72 TIMM8A 1678
Two-hybrid Homo sapiens
73 SNAP29 9342
Affinity Capture-MS Homo sapiens
74 TPM3 7170
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
75 CEP76  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PRKCDBP is involved
No pathways found





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