Gene description for PXMP4
Gene name peroxisomal membrane protein 4, 24kDa
Gene symbol PXMP4
Other names/aliases PMP24
Species Homo sapiens
 Database cross references - PXMP4
ExoCarta ExoCarta_11264
Vesiclepedia VP_11264
Entrez Gene 11264
HGNC 15920
UniProt Q9Y6I8  
 PXMP4 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PXMP4
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    ether lipid metabolic process GO:0046485 IEA
Subcellular Localization
    peroxisome GO:0005777 IDA
    peroxisomal membrane GO:0005778 IBA
    peroxisomal membrane GO:0005778 IDA
    peroxisomal membrane GO:0005778 ISS
    peroxisomal membrane GO:0005778 TAS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PXMP4 in sEVs
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for PXMP4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PGAM2 5224
Affinity Capture-MS Homo sapiens
2 PEX19 5824
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PXMP4 is involved
PathwayEvidenceSource
Class I peroxisomal membrane protein import TAS Reactome
Protein localization TAS Reactome





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