Gene description for ADAT3
Gene name adenosine deaminase, tRNA-specific 3
Gene symbol ADAT3
Other names/aliases FWP005
MRT36
MST121
MSTP121
S863-5
TAD3
Species Homo sapiens
 Database cross references - ADAT3
ExoCarta ExoCarta_113179
Vesiclepedia VP_113179
Entrez Gene 113179
HGNC 25151
MIM 615302
UniProt Q96EY9  
 ADAT3 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ADAT3
Molecular Function
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    tRNA-specific adenosine-34 deaminase activity GO:0052717 IBA
Biological Process
    tRNA processing GO:0008033 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified ADAT3 in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ADAT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRIP13 9319
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TRIP6 7205
Affinity Capture-MS Homo sapiens
3 KAT2A  
Affinity Capture-MS Homo sapiens
4 THRB 7068
Two-hybrid Homo sapiens
5 CDA 978
Two-hybrid Homo sapiens
6 POTEI 653269
Affinity Capture-MS Homo sapiens
7 RIT1 6016
Negative Genetic Homo sapiens
8 MED29  
Affinity Capture-MS Homo sapiens
9 BYSL 705
Affinity Capture-MS Homo sapiens
10 ARMC12  
Affinity Capture-MS Homo sapiens
11 EGFR 1956
Negative Genetic Homo sapiens
12 SAP30 8819
Affinity Capture-MS Homo sapiens
13 SELO 83642
Affinity Capture-MS Homo sapiens
14 USP47 55031
Affinity Capture-MS Homo sapiens
15 HMGN1  
Affinity Capture-MS Homo sapiens
16 ABLIM1 3983
Affinity Capture-MS Homo sapiens
17 TBC1D24 57465
Affinity Capture-MS Homo sapiens
18 SORBS3 10174
Two-hybrid Homo sapiens
19 FBLIM1 54751
Two-hybrid Homo sapiens
20 HSPA9 3313
Affinity Capture-MS Homo sapiens
21 TOM1 10043
Affinity Capture-MS Homo sapiens
22 ANKRD44 91526
Affinity Capture-MS Homo sapiens
23 ADAT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TLDC2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ADAT3 is involved
PathwayEvidenceSource
Metabolism of RNA TAS Reactome
tRNA modification in the nucleus and cytosol TAS Reactome
tRNA processing TAS Reactome





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